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WNT10A mutations often cause ectodermal dysplasias, with males showing more tooth issues than females.

Cancer treatments targeting specific cells and the immune system can cause skin, mouth, hair, and nail problems, affecting patients' quality of life and treatment adherence.

The document concludes that accurate diagnosis of ichthyosis is crucial for treatment and genetic advice, and ongoing research is needed for better therapies.

New treatments targeting specific genes show promise for treating keratin disorders.

Inherited ichthyoses cause widespread skin scaling and thickening due to gene mutations.

Understanding the genetics of rare inherited ichthyosis syndromes is key for better treatments and genetic counseling.

ALA-PDT is effective and safe for chronic X-ray dermatitis, providing complete or partial remission.

The study concluded that PKP1 is essential for skin integrity and hair growth, and its dysfunction causes the symptoms of ectodermal dysplasia/skin fragility syndrome.

New treatments for advanced skin cancer are improving patient outcomes, but drug resistance and finding the right treatment combinations are still big challenges.

Hair changes can indicate systemic diseases or medication effects.

Skin abnormalities can indicate immunodeficiency due to shared origins with the immune system.

A new gene variant in the DSP gene is linked to a unique type of hair loss.

People with alopecia areata often have thyroid autoimmunity.

AP-2α and AP-2β proteins are essential for healthy adult skin and hair.

Drug repositioning offers hope for new, affordable treatments for a genetic skin disorder called ARCI.

A baby from an Indian family had a rare genetic disorder causing no scalp or body hair due to a specific gene deletion.

Researchers found a genetic link for hereditary hair loss but need more analysis to identify the exact gene.

The chapter explains that there are many genetic skin disorders affecting skin cell formation, including both common and rare types.

Some skin conditions are associated with other serious diseases, and office microscopy may miss many fungal infections.

Certain gene mutations can weaken the skin barrier and, when combined with environmental factors, lead to eczema and severe itching.

Lichen Planus is a less common condition affecting skin and mucous membranes, with various types and associated risk factors, challenging to diagnose, significantly impacts life quality, and may have a risk of cancerous changes in oral lesions.

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

Some skin medications are safe during pregnancy and breastfeeding, but others can harm the baby and should be avoided.

The document concludes that recognizing and treating cutaneous lupus erythematosus early is crucial for managing the skin and potential systemic symptoms.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

KGF and activin are crucial for skin healing and repair.

Too much Smad7 can cause serious changes in skin tissues, including problems with hair growth, thymus shrinkage, and eye development issues.

Keratin 15 is not a reliable sole marker for identifying epidermal stem cells because it's found in various cell types.

Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.

Targeting the skin's endocannabinoid system could help treat skin disorders.