TLDR Drug repositioning offers hope for new, affordable treatments for a genetic skin disorder called ARCI.
The document discusses Autosomal recessive congenital ichthyoses (ARCI), a genetic skin disorder characterized by scaling and redness, which significantly impacts patients' quality of life. While topical treatments are commonly used for their convenience and affordability, oral retinoids are more effective but come with limitations. Since ARCI is a lifelong condition, there is a continuous need for new treatments. The review highlights drug repositioning as a promising approach to develop new, cost-effective therapies for ARCI by leveraging existing knowledge of drugs and biologics, potentially offering more accessible treatment options for patients.
21 citations,
July 2022 in “Orphanet journal of rare diseases” New treatments for ichthyosis, like protein replacement and gene therapy, show promise and may become standard care.
81 citations,
June 2012 in “European journal of human genetics” Inherited ichthyoses cause widespread skin scaling and thickening due to gene mutations.
44 citations,
January 2004 in “American journal of clinical dermatology” Understanding genetic mutations helps diagnose and treat skin disorders like ichthyosis.
147 citations,
January 2003 in “American journal of clinical dermatology” The document concludes that accurate diagnosis of ichthyosis is crucial for treatment and genetic advice, and ongoing research is needed for better therapies.
January 2022 in “Indian dermatology online journal” A baby with a skin condition improved with treatment but developed a rare form of the condition affecting only his trunk.
5 citations,
May 2018 in “Veterinary dermatology” Gluconolactone products can significantly reduce skin scaling in golden retrievers with ARCI.
August 2024 in “Veterinary Dermatology” Topical ceramide treatment partially improves the skin condition in Jack Russell Terriers with a genetic skin disorder.
18 citations,
January 2020 in “Acta dermato-venereologica” Over 67 genes linked to ichthyosis help improve diagnosis and treatment.
7 citations,
February 2019 in “Veterinary medicine and science” An American Bully with a genetic skin condition improved significantly with specific topical treatments.
