Topical Polyhydroxy Acid Treatment for Autosomal Recessive Congenital Ichthyosis in the Golden Retriever: A Prospective Pilot Study

    May 2018 in “ Veterinary dermatology
    Anna Puigdemont, Nicla Furiani, Michela De Lucia, Isaac Carrasco, Laura Ordeix, Dolors Fondevila, Laura Ramió‐Lluch, Pilar Brazı́s
    TLDR Gluconolactone products can significantly reduce skin scaling in golden retrievers with ARCI.
    The study investigated the efficacy of a topical treatment containing gluconolactone for autosomal recessive congenital ichthyosis (ARCI) in 16 golden retrievers with a PNPLA1 gene mutation. The treatment regimen involved using a shampoo and lotion initially twice weekly, then once weekly, and finally once monthly. Results showed a significant reduction in the extent and size of scales by 60% and 75% after 14 and 30 days, respectively (P < 0.001). In 20% of the dogs, scaling was completely resolved after 30 days. No other skin lesions or pruritus were observed, and post-treatment biopsies indicated normalization of the stratum corneum and reduced hyperpigmentation. The study concluded that frequent use of gluconolactone-based products could effectively improve skin scaling in golden retrievers with ARCI.
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