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Certain mutations in the H6PD gene cause Cortisone Reductase Deficiency by affecting hormone production.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

Human sebaceous glands contain enzymes that affect androgen production and may influence sebum production and acne.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Blocking glucocorticoid receptors improves glucose metabolism in a PCOS mouse model.

The Rotterdam Study investigates diseases in older adults and has produced many research findings.

The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

Polycystic Ovary Syndrome (PCOS) is a common condition in women that can cause metabolic, reproductive, and psychological issues, and requires lifestyle changes and medication for management.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

The Rotterdam Study aims to understand various diseases in older adults.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

ZDHHC13 is important for normal liver function and metabolism, affecting mitochondrial activity.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

Low doses of mixed chemicals cause permanent reproductive malformations in male rats.

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.

Hormonal treatments are effective as a second-line option for moderate-to-severe acne in females, but should be used with caution due to health risks.

Certain genetic variations are linked to increased androgen levels in PCOS, but more research is needed to understand these connections fully.

Higher androstenedione levels in women with PCOS are linked to more severe symptoms.

Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.

Blocking the FGF5 gene in sheep leads to more fine wool and active hair follicles due to changes in certain cell signaling pathways.

Mice with LSS deficiency showed hair loss and cataracts, similar to humans, and can help in understanding and treating this condition.

Cholesterol-related compounds can stop hair growth and cause inflammation in a type of scarring hair loss.