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This study explored the structure and function of lipocalin prostaglandin D synthase, revealing its dual role in substrate catalysis and as a lipophilic ligand carrier, potentially informing future drug delivery design.

This phase I study found that MK-2206 was well tolerated and demonstrated evidence of AKT signaling blockade in patients with advanced solid tumors, with the maximum-tolerated dose established at 60 mg.

This study found that using a hair removal laser can effectively reduce hair thickness in the hairline of Asian women with thick donor hairs from previous hair transplants, improving hairline appearance with mild, transient side effects.

This abstract explains that dandruff can be treated using either chemical-based or herbal anti-dandruff shampoos, with both types containing antibacterial and antifungal ingredients to reduce scalp flakiness and eliminate fungi.

This review discusses the role of androgen hormones in skin and hair conditions and highlights the potential of antiandrogen therapies in dermatology, reporting no new results.

In this study, researchers developed a herbal shampoo using natural plant extracts, which maintained physicochemical properties and improved hair texture without the side effects commonly associated with synthetic ingredients.

This source outlines various antiandrogen and androgen inhibitor drugs used to treat cutaneous disorders of hyperandrogenism, detailing their mechanisms, uses, dosages, and side effects, with emphasis on spironolactone, finasteride, dutasteride, and oral contraceptives.

Anti-androgens are effective for female acne but less so for male-pattern hair loss, with side effects similar to birth control pills.

In this study, a herbal preparation inhibited the conversion of testosterone to DHT and its binding on hair roots in vitro, suggesting potential as an alternative treatment for androgenic alopecia without the safety concerns associated with finasteride.

This study found that Rosebay extract significantly reduced dandruff and sebum production, suggesting it may be an effective anti-dandruff ingredient as a complement or alternative to antifungal treatments.

RU58841, a substance from France, can potentially block the effects of hormones that cause hair loss and excessive hair growth, performing better than a similar substance, cyproterone acetate.

This article reviews the effects of 5 alpha-reductase inhibitors for treating conditions like male pattern baldness and benign prostatic hyperplasia, noting significant DHT reduction but reports no new clinical results.

In this study, DPHC from the brown alga Ishige okamurae demonstrated potential to prevent androgenic alopecia by inhibiting hair loss and promoting hair growth through multiple cellular mechanisms.

In this randomized trial, a solid shampoo formulated with plant extracts was more effective than placebo in improving androgenetic alopecia and reducing hair cortisol and DHT concentrations in men.

This study formulated and evaluated a polyherbal anti-dandruff shampoo, demonstrating it had good cleansing properties, antimicrobial activity against dandruff-causing microbes, and remained physically stable, potentially offering a safe and effective herbal alternative for dandruff management.

This review discusses the use of antiandrogen therapy in dermatology, covering treatments for conditions like acne, hirsutism, and androgenic alopecia but reports no new clinical findings.

In this study, researchers developed a polyherbal antidandruff shampoo using medicinal plant extracts and found it exhibited significant antioxidant and antimicrobial properties, including activity against bacteria and fungi linked to scalp infections, suggesting it as a natural alternative to synthetic shampoos.

In this study, the researchers investigated the effectiveness of shampoo containing herbal extracts, specifically Neem and Tulsi, for managing dandruff and found it may offer benefits compared to synthetic drugs, which often cause side effects.

This study aimed to create and assess an herbal shampoo that prioritizes safety, efficacy, and quality, as an alternative to conventional shampoos that can cause side effects such as hair loss and scalp irritation.

This study found that a shampoo containing a 6-active ingredient complex increased β-Catenin production in human hair follicle dermal papilla cells to levels comparable to Finasteride, suggesting potential for promoting hair growth. It also showed good cleaning efficacy, volume, and shine in a sensorial study.

This article discusses the potential use of 5α-reductase inhibitors in dermatology and reports no new clinical results; the authors suggest further exploration of their dermatological applications.

This study suggests that topical finasteride may benefit women with facial hirsutism, based on observations from a small sample.

This review discusses the roles of dihydrotestosterone in fetal development and adult diseases, reporting no new clinical results; the authors emphasize the potential of 5α-reductase inhibitors for treatment.

This source describes alopecia as a hair loss condition often driven by genetic and androgenic factors, with lifestyle elements like chemical treatments exacerbating the issue; Ayurvedic texts caution against scalp toxins and suggest traditional formulations for support.

This study developed a herbal-based anti-dandruff shampoo using plant extracts, which demonstrated effective cleaning and anti-dandruff properties without adverse effects compared to synthetic options.

This study aimed to formulate and evaluate an herbal anti-dandruff shampoo using natural ingredients, prioritizing safety and efficacy to minimize side effects commonly associated with synthetic shampoos.

This study found that the polyherbal anti-dandruff shampoo formulated from medicinal plants like Azadirachta indica and Hibiscus rosa-sinensis demonstrated significant antioxidant and antimicrobial activities, including effects against dandruff-causing microorganisms, suggesting it could be a natural alternative to synthetic shampoos.

This study found that a herbal shampoo and solution were more effective than placebo in reducing hair loss and improving hair growth in participants with androgenetic alopecia and telogen effluvium.

This study formulated and evaluated a herbal anti-dandruff shampoo using natural ingredients, finding that it effectively reduced dandruff, improved scalp and hair health, and presented an economical and safe alternative to synthetic shampoos without significant skin irritation.

This study formulated an herbal anti-dandruff shampoo powder using Nyctanthes arbortristis as the main ingredient, and found that it exhibited significant anti-dandruff properties, beneficial physicochemical characteristics, and promising in-vitro results compared to a marketed medicated product.