Search

everythinglearnresearchcommunity

for

Search:↓

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

Compartmentalized organization might be crucial for stem cells to effectively respond to growth or injury.

The study showed that hair follicle stem cells can maintain and organize themselves in a lab setting, keeping their ability to renew and form hair and skin.

Most hair follicle stem cells do not protect their DNA by dividing it unevenly.

Immunosuppressive and anti-TNF therapies in IBD patients can increase the risk of skin cancer and cause various skin issues.

The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.

A position effect on the TRPS1 gene causes excessive hair growth in humans and mice.

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.

Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.

Wnt signaling may be linked to heart diseases in aging and could be a target for future treatments.

Male pattern baldness is mostly inherited, involves many genes, and is linked to other traits like early puberty and strong bones.

Products should be called 'sperm-safe' only after thorough, well-designed tests.

High levels of testosterone and 5α-DHT can lead to cell death in cells important for hair growth.

Testosterone may slow down wound healing and increase inflammation.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

Skin stem cells maintain and repair the outer layer of skin, with some types being essential for healing wounds.

Cyclosporin A helps mice grow hair by blocking a specific protein activity in skin cells.

Hair can regrow after certain stem cells are lost because other stem cells can take over their role.

Two-photon microscopy helps observe hair follicle stem cell behaviors in mice.

Older skin has higher cancer risk due to inflammation and stem cell issues.

The guide explains how to study human and mouse sebaceous glands using various staining and imaging techniques, and emphasizes the need for standardized assessment methods.

Human hair contains diverse proteins, including keratins and histones, which could help assess hair health and aging.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Mice without Vitamin D receptors have hair growth problems because of issues in the hedgehog signaling pathway.

Brg1 is crucial for hair growth and skin repair by maintaining stem cells and promoting regeneration.

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.

The document concludes that while there are promising methods to control CRISPR/Cas9 gene editing, more research is needed to overcome challenges related to safety and effectiveness for clinical use.

Small molecule drugs show promise for advancing regenerative medicine but still face development challenges.

The drug enzalutamide may reduce the ability of the virus causing COVID-19 to enter lung cells.

Dupilumab is being tested for many new skin, respiratory, and gastrointestinal conditions.