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![Enhancing Diagnostic Yield of Monogenic Diabetes Through Phenotypic and Molecular Reanalysis of 128 Individuals With Young Onset Hyperglycemia: Highlighting the Significance of Accurate Case Characterization](/images/research/d27589a9-c8b8-4f19-b806-78499c3feffc/small/36390.jpg)
research Enhancing Diagnostic Yield of Monogenic Diabetes Through Phenotypic and Molecular Reanalysis of 128 Individuals With Young Onset Hyperglycemia: Highlighting the Significance of Accurate Case Characterization
Combining genetic and physical trait analysis improves diagnosis accuracy for monogenic diabetes.
![The Multiple Consequences Of Obesity](/images/research/45a39abd-83b9-4548-9cef-2a6ad8654821/small/13035.jpg)
research The Multiple Consequences Of Obesity
Obesity leads to physical, metabolic, reproductive issues, higher healthcare costs, and mental health problems.
![Polycystic Ovary Syndrome (PCOS) – An Overview](/images/research/72b67078-95f1-4ca8-a3cd-a254e0a6850a/small/13698.jpg)
research Polycystic Ovary Syndrome (PCOS) – An Overview
PCOS is a hormonal disorder causing symptoms like irregular periods and acne, and increases the risk of diabetes and heart disease.
![Metabolic Syndrome and Skin Disease: Potential Connection and Risk](/images/research/89e24d16-f7ae-4b9e-b4ba-d29acbb8accb/small/20894.jpg)
research Metabolic Syndrome and Skin Disease: Potential Connection and Risk
Some skin diseases may indicate a higher risk of metabolic syndrome and related health issues.
![Understanding Polycystic Ovary Syndrome](/images/research/97a7f1a6-b8e8-4c18-bff2-860d32f539e0/small/20379.jpg)
research Understanding Polycystic Ovary Syndrome
PCOS affects many women, causing various symptoms and health risks, and is managed through lifestyle changes, medication, and support groups.
![Clinical Aspects of the Metabolic Syndrome](/images/research/bc037a93-4120-49a7-a2a7-3074309aebfe/small/18080.jpg)
research Clinical Aspects of the Metabolic Syndrome
Losing weight and eating better are key to managing metabolic syndrome and its related conditions.
![Lean Women with Polycystic Ovary Syndrome](/images/research/2083c0d2-1cb1-429b-8d0c-7b3b00ccd85d/small/13754.jpg)
research Lean Women with Polycystic Ovary Syndrome
PCOS in lean women is a serious health condition with implications beyond fertility, affecting metabolism and increasing cardiovascular disease risk.
![COVID-19 and Hypopituitarism](/images/research/b4249819-b772-4d94-bdb0-57d2864a6dd8/small/13197.jpg)
research COVID-19 and Hypopituitarism
COVID-19 and hypopituitarism (reduced pituitary gland function) are linked, with the latter's related health issues potentially worsening COVID-19 outcomes, and COVID-19 possibly increasing risk for pituitary complications.
![Mucocutaneous Manifestations of Endocrine Disorders](/images/research/b3399203-3726-47fe-9b97-a5fba0491505/small/14365.jpg)
research Mucocutaneous Manifestations of Endocrine Disorders
Skin symptoms can indicate endocrine disorders and have various treatments.
![Case 18-2018: A 45-Year-Old Woman with Hypertension, Fatigue, and Altered Mental Status](/images/research/bd5777e1-732f-485a-82e7-c73851846fa9/small/13751.jpg)
research Case 18-2018: A 45-Year-Old Woman with Hypertension, Fatigue, and Altered Mental Status
A woman with Cushing's syndrome improved after surgery to remove a tumor causing the condition.
![Use of Insulin-Sensitizing Agents in Patients With Polycystic Ovary Syndrome](/images/research/ad79d13d-6cb5-4117-8721-7757c9e3be4a/small/15483.jpg)
research Use of Insulin-Sensitizing Agents in Patients With Polycystic Ovary Syndrome
Insulin-sensitizing drugs like metformin can help with ovulation, weight loss, and lower testosterone in some women with PCOS.
![Trends in Nanotechnology for Practical Applications](/images/research/1b70680c-730b-414d-be48-cdd108b23e8b/small/13443.jpg)
research Trends in Nanotechnology for Practical Applications
Nanotechnology is improving drug delivery and targeting, with promising applications in cancer treatment, gene therapy, and cosmetics, but challenges remain in ensuring precise delivery and safety.
![Ameliorative Effects of Rutin Against Metabolic, Biochemical, and Hormonal Disturbances in Polycystic Ovary Syndrome in Rats](/images/research/d41a39e8-97e0-427d-a34f-b2966500c3fb/small/13973.jpg)
research Ameliorative Effects of Rutin Against Metabolic, Biochemical, and Hormonal Disturbances in Polycystic Ovary Syndrome in Rats
Rutin may help treat symptoms of polycystic ovary syndrome (PCOS) in rats.
![Polycystic Ovary Syndrome: Insight Into Pathogenesis and a Common Association With Insulin Resistance](/images/research/5ee2318f-478f-4e84-994b-ec23c4f0a7fd/small/14262.jpg)
research Polycystic Ovary Syndrome: Insight Into Pathogenesis and a Common Association With Insulin Resistance
Improving insulin sensitivity and weight loss can help manage polycystic ovary syndrome (PCOS).
![Risks for Metabolic Syndrome and Cardiovascular Diseases in Both Male and Female Patients with Androgenetic Alopecia](/images/research/83104a71-0192-4d7a-a555-e1ed39d8352c/small/3631.jpg)
research Risks for Metabolic Syndrome and Cardiovascular Diseases in Both Male and Female Patients with Androgenetic Alopecia
People with androgenetic alopecia, both men and women, are more likely to develop heart diseases in the future.
![Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome KATP Channel Mutations in Intact Cells](/images/research/c7ea3e0e-272f-42db-bd9e-c7c374635f2e/small/33004.jpg)
research Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome KATP Channel Mutations in Intact Cells
Kir6.1 mutations in Cantú syndrome increase channel sensitivity and hyperpolarization, while SUR2B mutations do not.
research Effects of Orlistat on Serum Androgen Levels Among Iranian Obese Women With Polycystic Ovarian Syndrome
Orlistat helped reduce weight and testosterone in obese women with PCOS but did not significantly affect other androgens or cholesterol levels.
![Vitamin D Receptor Polymorphisms and Polycystic Ovary Syndrome: A Systematic Review](/images/research/565bc11f-1b4b-4226-b77b-7332086be136/small/13877.jpg)
research Vitamin D Receptor Polymorphisms and Polycystic Ovary Syndrome: A Systematic Review
The review found no clear link between vitamin D receptor gene variations and polycystic ovary syndrome.
![Oral Combination Treatment of Gefitinib and Sasam-Kyeongokgo: Synergistic Effects on the NCI-H520 Tumor Cell Line](/images/research/16aee7e5-e478-4617-858c-dea397c9f193/small/22782.jpg)
research Oral Combination Treatment of Gefitinib and Sasam-Kyeongokgo: Synergistic Effects on the NCI-H520 Tumor Cell Line
Gefitinib and Sasam-Kyeongokgo together significantly reduce cancer growth and improve immune response in mice.
![Serum Vascular Endothelial Growth Factor B Is Elevated in Women With Polycystic Ovary Syndrome and Can Be Decreased With Metformin Treatment](/images/research/30920850-de86-4ab3-aab4-a76afda2b37d/small/14246.jpg)
research Serum Vascular Endothelial Growth Factor B Is Elevated in Women With Polycystic Ovary Syndrome and Can Be Decreased With Metformin Treatment
Women with PCOS have higher levels of a certain growth factor, which can be reduced by taking metformin.
![Androgenetic Alopecia as an Early Marker of Benign Prostatic Hyperplasia](/images/research/87339ffe-8383-49ca-bc98-dad1cff7c659/small/3141.jpg)
research Androgenetic Alopecia as an Early Marker of Benign Prostatic Hyperplasia
Early hair loss may indicate prostate issues.
![Progressive Metabolic Dysfunction-Associated Steatotic Liver Disease from a Young Age Due to a Rare Genetic Disorder, Familial Partial Lipodystrophy: A Case Report and Review of the Literature](/images/research/56486a59-b5ad-4665-b7b1-3aefa3f2bf40/small/40899.jpg)
research Progressive Metabolic Dysfunction-Associated Steatotic Liver Disease from a Young Age Due to a Rare Genetic Disorder, Familial Partial Lipodystrophy: A Case Report and Review of the Literature
Recognizing rare causes of MASLD is crucial for effective treatment and preventing complications.
![Predisposing and Overall Effects of Reproductive Hormones on Breast Cancer: A Review](/images/research/7a666f9f-dd31-4567-a14d-88e36d27008f/small/36621.jpg)
research Predisposing and Overall Effects of Reproductive Hormones on Breast Cancer: A Review
Reproductive hormones play a crucial role in breast cancer development and treatment challenges.
![Association of Gly972Arg Variant of Insulin Receptor Substrate-1 and Gly1057Asp Variant of Insulin Receptor Substrate-2 with Polycystic Ovary Syndrome in the Chinese Population](/images/research/c37d9aa6-3209-4327-827d-2ac493713776/small/14395.jpg)
research Association of Gly972Arg Variant of Insulin Receptor Substrate-1 and Gly1057Asp Variant of Insulin Receptor Substrate-2 with Polycystic Ovary Syndrome in the Chinese Population
The IRS-2 Asp/Asp genotype may increase the risk of PCOS in Chinese women, especially if they are not obese.
![Nesfatin-1 and Vitamin D Levels May Be Associated with Systolic and Diastolic Blood Pressure Values and Heart Rate in Polycystic Ovary Syndrome](/images/research/79f19c62-a2db-4f5b-85de-df304b239019/small/20981.jpg)
research Nesfatin-1 and Vitamin D Levels May Be Associated with Systolic and Diastolic Blood Pressure Values and Heart Rate in Polycystic Ovary Syndrome
High Nesfatin-1 and low Vitamin D may increase blood pressure and heart rate in women with PCOS.
![Sex Hormone–Binding Globulin and Risk of Hyperglycemia in Patients With Androgenetic Alopecia](/images/research/dfca8bd0-4382-4bc3-a544-45e2705b254e/small/3072.jpg)
research Sex Hormone–Binding Globulin and Risk of Hyperglycemia in Patients With Androgenetic Alopecia
People with hair loss have higher risk of high blood sugar and diabetes, and lower levels of a specific hormone.
![The Investigation of Insulin Resistance and Metabolic Syndrome in Male Patients with Early-Onset Androgenetic Alopecia](/images/research/bcdf0e66-553b-4753-a99a-f95e92dddca8/small/3044.jpg)
research The Investigation of Insulin Resistance and Metabolic Syndrome in Male Patients with Early-Onset Androgenetic Alopecia
Early balding men may have insulin resistance, but lifestyle changes can help.
![Glycolipid and Hormonal Profiles in Young Men with Early-Onset Androgenetic Alopecia: A Meta-Analysis](/images/research/449e7317-1f81-45a2-b498-2e15afe4b4bf/small/4102.jpg)
research Glycolipid and Hormonal Profiles in Young Men with Early-Onset Androgenetic Alopecia: A Meta-Analysis
Young men with early hair loss have slightly worse blood sugar and fat levels, suggesting possible health risks and need for monitoring.
![Medical Complications of Anorexia Nervosa and Bulimia Nervosa](/images/research/92d127fb-6da2-4e39-a441-e49484518237/small/24928.jpg)
research Medical Complications of Anorexia Nervosa and Bulimia Nervosa
Anorexia and bulimia lead to serious health problems and increased risk of death, requiring aggressive treatment.