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This study found that long-term dutasteride therapy in men with benign prostatic hyperplasia worsened erectile dysfunction, reduced testosterone levels, and increased blood glucose and lipid profile, indicating negative metabolic impacts.

In this study, the safety of finasteride in rats varied depending on dosing time, while its effectiveness on prostate weight reduction remained consistent.

This study suggests that dysfunctions and altered expression of aquaporins may play a role in PCOS-related disorders, potentially impacting folliculogenesis and integrating with the insulin-dependent hypothesis of PCOS pathogenesis.

This article reviews the physiological skin changes and unique dermatoses in pregnancy, discussing their causes and management, but reports no new clinical findings.

This review discusses the role of androgens in women's sexual health and highlights the need for further research on androgen replacement therapy to optimize quality of life, but reports no new clinical results.

This article discusses the importance of interpreting laboratory data and performing physical assessments to support pharmacists in clinical decision-making and patient consultations, but reports no new empirical findings.

This study found that experimentally induced hypothyroidism in rats is associated with impaired skin structure, but topical application of triiodothyronine (T3) improved these changes to resemble normal skin.

In this study, periodic exposure to red light in aged mice led to increased histone acetylation and activated mitochondrial fatty acid oxidation, which collectively mitigated cellular aging by modulating metabolism, inflammation, and gene expression.

This review highlights that isotretinoin effectively treats acne by addressing its pathogenic mechanisms, although managing its teratogenic risk and side effects through structured monitoring is crucial for safe use.

This review article highlights that obesity is a significant risk factor for several inflammatory skin conditions, such as psoriasis and atopic eczema, contributing to increased overall morbidity among those affected.

This review examines the role of androgens and androgen receptors in regulating glucose and lipid metabolism, focusing on their effects on mitochondrial content and function; it also discusses the sex-dimorphic influence of androgens and provides theoretical insights into their mechanisms.

This review discusses the paracrine properties of cardiac stem cells and pericytes in regenerative medicine for ischaemic diseases and reports no new clinical results.

This study observed that female mice with disrupted 5α-reductase 1 showed increased insulin resistance and hepatic steatosis, suggesting altered glucocorticoid metabolism contributes to metabolic disorders.

This book chapter discusses the mechanisms and prevention of selenium toxicity in livestock and reports no new experimental results; it emphasizes reducing selenium in the human food chain through animal products.

This article reviews the care of transgender patients, encompassing diagnosis, treatment options, and challenges in health care access, but does not present new research findings; the authors emphasize the critical role of providers in addressing transgender health needs.

This review discusses methotrexate's use in dermatology and its mechanisms, pharmacokinetics, dosing, side effects, interactions, and emphasizes the need for further research into optimizing therapy and predicting adverse events.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

This review discusses the evaluation of hyperandrogenemia in women and hypogonadism in men across different life stages and presents biomarkers used for diagnosing male hypogonadism, reporting no new clinical results.

This review supports iron deficiency anemia as a valid cause of chronic generalized pruritus and suggests potential mechanisms by which iron deficiency may lead to pruritus, but reports no new clinical results.

This study found that dietary vitamin E influenced gene expression in rat livers, altering genes related to metabolism, coagulation, and steroid processing, and confirmed its effects on related biological endpoints.

This study found that the vitamin D-VDR system is crucial for mineral and bone metabolism post-weaning and identified missense mutations in 1alpha-hydroxylase causing type I rickets.

This study found that loss of epidermal PPARγ in mice altered the expression of many genes related to skin inflammation, keratinization, and sebaceous gland function, indicating its key role in maintaining skin homeostasis.

This review highlights the connection between sex hormones and metabolic dysfunction, emphasizing how conditions like male hypogonadism and female hyperandrogenism can increase the risk and severity of hepatic steatosis, which often progresses alongside metabolic syndrome and elevates mortality risks.

This review examines how GLP-1 receptor agonists might impact metabolic and reproductive outcomes in polycystic ovary syndrome, but it reports no new clinical findings and highlights the need for further research.

This review discusses the potential of optical techniques for diagnosing and treating oxidative stress-related hepatic ischemia-reperfusion injury, highlighting the need for non-invasive diagnostic methods and the anti-oxidative potential of optical therapies; it reports no new clinical results.

This review discusses the role of lncRNA Xist in cell growth regulation and disease development, particularly cancer, and reports no new experimental results.

This review discusses the paracrine function of mesenchymal stem cells in tissue regeneration and repair, focusing on secreted bioactive substances and their role under different microenvironments; it reports no new clinical results.

This study found that the acyl-CoA binding protein is essential for the production of very long chain free fatty acids in the stratum corneum and maintaining normal epidermal barrier function in mice.

A novel mutation in the SLC39A4 gene was identified in an infant with mild, incomplete acrodermatitis enteropathic symptoms, suggesting genetic testing is beneficial even without the full symptom triad.

This study reviews the role of the zinc finger protein CXXC5 in cellular signaling and its implications for cancer, discussing how its dysregulation is linked to various physiological and pathological processes, as well as potential therapies targeting CXXC5.