10 citations
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September 2023 in “Metabolites” This study reviews iron metabolism in the skin, highlighting how differentially expressed genes regulate iron recycling in the epidermis, and discusses changes in iron metabolism related to skin diseases.
July 2020 in “Family Medicine” This review describes the role of iron deficiency in hair loss and explores the management of diffuse alopecia, emphasizing the potential of a new iron-based dietary supplement but reports no new clinical results.
July 2026 in “Journal of the American Academy of Dermatology” No direct link between matcha green tea and hair loss is proven.
9 citations
,
February 2024 in “mBio” This study found that biliverdin beta and delta, metabolites of heme, play a critical role in Pseudomonas aeruginosa iron acquisition and cooperative behaviors, which are crucial for the bacterium's long-term infection in cystic fibrosis patients, suggesting potential targets for new therapies.
11 citations
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October 2023 in “mSphere” This study reported that the PrrH sRNA in *Pseudomonas aeruginosa* may directly regulate genes involved in pyochelin siderophore biosynthesis, highlighting its role in adapting to heme availability, with light conditions influencing this gene expression.
4 citations
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January 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study identified the genes for pyochelin siderophore biosynthesis as a novel target regulated by the heme-responsive PrrH sRNA in Pseudomonas aeruginosa.
9 citations
,
July 2018 in “Current Pharmaceutical Design” This review discusses the importance of heme oxygenase in skin physiology and disease, but it reports no new clinical results; the authors highlight its potential as a treatment target for conditions like atopic dermatitis and psoriasis.
November 2018 in “Springer eBooks” Children need early diagnosis and treatment for iron-deficiency anemia to prevent learning problems and promote health.
207 citations
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April 2006 in “Journal of The American Academy of Dermatology” This review discusses the complexities of diagnosing and treating iron deficiency related to nutritional anemia and hair loss, concluding that routine screening and supplementation for hair loss are not yet supported by sufficient evidence.
June 2026 in “Ginekologia Polska” This study found that supplementation with micronized and emulsified ferric pyrophosphate effectively improved lab test results and reduced iron deficiency symptoms in patients aged 19-70, with the majority reporting good tolerance and few side effects.
April 2026 in “Al-Kufa University Journal for Biology” This pilot study observed that post-bariatric surgery, both zinc and iron deficiencies increased among Iraqi patients, underscoring the importance of lifelong nutritional monitoring and targeted supplementation to address these issues and prevent related complications.
January 2018 in “International journal of food and nutrition research” Intermittent iron and nutritional supplements can help reduce hair loss.
22 citations
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November 2008 in “International Journal of Dermatology” This study suggests that a mixture of 5‐ALA and iron ion significantly improved hair growth in mice, comparable to minoxidil, without promoting keratinocyte or fibroblast proliferation in vitro.
30 citations
,
October 2010 in “Journal of The American Academy of Dermatology” This review examines the debated link between iron deficiency and nonscarring scalp alopecia in women, offering no new clinical results but emphasizing the need for further research and well-designed trials.
May 2026 in “AlQalam Journal of Medical and Applied Sciences” In this study, researchers found that relying solely on ferritin to assess iron status in young females with higher BMI may lead to inaccurate diagnoses of iron deficiency due to inflammation-related ferritin elevation.
9 citations
,
October 2010 in “Journal of the American Academy of Dermatology” Iron deficiency might cause hair loss, but better testing is needed.
7 citations
,
February 2017 in “The American journal of medicine” This case report describes a 34-year-old woman who, after Roux-en-Y gastric bypass surgery, experienced improvements in symptoms of dizziness and energy following treatment with oral ferrous sulfate for iron deficiency.
24 citations
,
May 2019 in “PLOS genetics” This study reports that compound heterozygous loss-of-function mutations in the HEPHL1 gene in a child were associated with abnormal hair and cognitive issues, linking altered ferroxidase activity to hair disorders.
14 citations
,
January 2006 in “Journal of Investigative Dermatology” This study found that controlling transferrin receptor expression effectively regulates iron content in the epidermis and hair of transgenic mice.
January 2026 in “Journal of Trace Elements in Medicine and Biology” This study found that living environment significantly influenced Fe concentrations in dog and cat hair, with outdoor animals showing higher levels than those kept indoors.
April 2024 in “Journal of environmental management” This study investigated the electron transfer processes in an iron-mediated DAMO–anammox system, finding that Fe3+ accelerated c-type cytochrome-mediated electron transfer and suggested that riboflavin acts as an electron shuttle and DIET may occur among these microorganisms.
6 citations
,
August 2023 in “Journal of Investigative Dermatology” This study investigated how keratinocytes in the skin respond to different iron levels and found they play a significant role in regulating iron homeostasis by storing iron, affecting epidermal differentiation, and influencing inflammation-related gene expression in mice.
October 2025 in “Journal of Investigative Dermatology” This review highlights the critical role of iron in skin functions and suggests potential dermatologic therapies targeting the iron-skin axis.
53 citations
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July 2014 in “American Journal of Physiology-Endocrinology and Metabolism” This study found that testosterone-enanthate increased red blood cell production and altered iron homeostasis in older hypogonadal men without being affected by finasteride, indicating these effects do not require type II 5α-reductase enzyme activity.
4 citations
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June 2019 in “International Journal of Cosmetic Science” This study developed mathematical models showing that heat penetrates individual hair quickly but takes longer to reach the center of hair bundles, helping understand potential damage from high-temperature styling tools.
September 2025 in “Romanian Journal of Medical Practice” In this study of women with female pattern hair loss, iron deficiency was associated with the condition due to significantly lower serum ferritin and altered hematological indices compared to healthy controls, while no significant differences in serotonin levels or renal function were observed.
January 2015 in “Springer eBooks” Chronic kidney disease can cause hair loss, which may be related to zinc deficiency or certain medications, and sometimes hair grows back when the underlying issue is treated.
79 citations
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January 2017 in “Dermatology practical & conceptual” This article addresses the need to screen for nutrient deficiencies in patients with hair loss but reports no new findings, noting that supplementation without deficiency may not be beneficial and could pose risks.
15 citations
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January 2016 in “Przeglad Menopauzalny” This review discusses the role of diet in managing hair loss during menopause and reports no new clinical results; it highlights the importance of nutrients like sulfur amino acids, vitamins, and minerals.
2 citations
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November 2022 in “Bioscience Reports” This review explores the similarities between polycystic ovary syndrome and hemochromatosis in terms of iron overload and suggests that addressing gut dysbiosis might help manage iron levels in these conditions.