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    Did you mean Hedgehog signaling pathway?
    Glossary Hedgehog signaling pathway

    regulates cell growth and development through protein-receptor interactions

    The Hedgehog signaling pathway is a crucial mechanism in developmental biology that regulates cell growth, differentiation, and tissue patterning. It involves the Hedgehog proteins binding to receptors on cell surfaces, which then trigger a cascade of intracellular events that influence gene expression. This pathway is essential for proper embryonic development and, when dysregulated, can lead to conditions such as cancer and congenital disorders.

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    1. Conditional Disruption of Hedgehog Signaling Pathway Defines its Critical Role in Hair Development and Regeneration Journal of Investigative Dermatology · 2000 · 194 citations
    2. MIM and Cortactin Antagonism Regulates Ciliogenesis and Hedgehog Signaling Developmental Cell · 2010 · 118 citations
    3. Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway Journal of Investigative Dermatology · 2005 · 113 citations
    4. Hedgehog signaling is essential for normal wound healing Wound Repair and Regeneration · 2008 · 112 citations
    5. Overexpression of Hedgehog Signaling Is Associated with Epidermal Tumor Formation in Vitamin D Receptor–Null Mice Journal of Investigative Dermatology · 2011 · 100 citations
    6. Roles of the Hedgehog Signaling Pathway in Epidermal and Hair Follicle Development, Homeostasis, and Cancer Journal of developmental biology · 2017 · 72 citations
    7. Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin Aging Cell · 2009 · 62 citations
    8. AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma Nature Communications · 2020 · 60 citations
    9. The Vitamin D Receptor Is Required for Activation of cWnt and Hedgehog Signaling in Keratinocytes Molecular Endocrinology · 2014 · 56 citations
    10. Disruption of the hedgehog signaling pathway contributes to the hair follicle cycling deficiency in Vdr knockout mice Journal of Cellular Physiology · 2010 · 53 citations
    11. Hedgehog Signaling, Keratin 6 Induction, and Sebaceous Gland Morphogenesis American Journal Of Pathology · 2008 · 33 citations
    12. Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state Developmental cell · 2022 · 25 citations
    13. Hedgehog and Gli Signaling in Embryonic Mammary Gland Development Journal of mammary gland biology and neoplasia · 2013 · 25 citations
    14. Hes1 regulates anagen initiation and hair follicle regeneration through modulation of hedgehog signaling Stem Cells · 2019 · 20 citations
    15. Basal Cell Carcinoma, Hedgehog Signaling, and Targeted Therapeutics: The Long and Winding Road Journal of Investigative Dermatology · 2014 · 15 citations
    16. Exosomes Derived From Human Adipose-Derived Stem Cells Inhibit Lipogenesis Involving Hedgehog Signaling Pathway Frontiers in Bioengineering and Biotechnology · 2021 · 13 citations
    17. LncRNA-XIST promotes dermal papilla induced hair follicle regeneration by targeting miR-424 to activate hedgehog signaling Cellular Signalling · 2020 · 11 citations
    18. The E6/E7 oncogenes of human papilloma virus and estradiol regulate hedgehog signaling activity in a murine model of cervical cancer Experimental Cell Research · 2019 · 9 citations
    19. Hedgehog Signaling in Papillary Fibroblasts Is Essential for Hair Follicle Regeneration during Wound Healing Journal of Investigative Dermatology · 2021 · 5 citations
    20. Epidermal-Derived Hedgehog Signaling Drives Mesenchymal Proliferation during Digit Tip Regeneration Journal of Clinical Medicine · 2021 · 3 citations
    21. Dermal Hedgehog Signaling in Papillary Fibroblasts: An Emerging Key Player in Skin Regeneration Journal of Investigative Dermatology · 2022 · 2 citations
    22. The GPR30 agonist G-1 promotes hair growth via Wnt/Hedgehog signaling in mice Frontiers in Pharmacology · 2025
    23. Author response: Coordinated hedgehog signaling induces new hair follicles in adult skin 2019
    24. Decision letter: Coordinated hedgehog signaling induces new hair follicles in adult skin 2019
    25. Vitamin E promotes dermal papilla cell proliferation via the lncRNA2919/STAT1 axis to activate the Hedgehog signaling pathway Non-coding RNA Research · 2026
    26. Roles of the Hedgehog Signaling Pathway in Cutaneous Physiology and Oncology International journal of dermatology and venereology · 2019
    27. Hedgehog signalling in skin development and cancer Experimental Dermatology · 2006 · 190 citations
    28. WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling Experimental & Molecular Medicine · 2021 · 36 citations
    29. Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation FEBS Journal · 2021 · 23 citations
    30. Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways Frontiers in pharmacology · 2018 · 14 citations