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    Did you mean Hedgehog signaling pathway?
    Glossary Hedgehog signaling pathway

    regulates cell growth and development through protein-receptor interactions

    The Hedgehog signaling pathway is a crucial mechanism in developmental biology that regulates cell growth, differentiation, and tissue patterning. It involves the Hedgehog proteins binding to receptors on cell surfaces, which then trigger a cascade of intracellular events that influence gene expression. This pathway is essential for proper embryonic development and, when dysregulated, can lead to conditions such as cancer and congenital disorders.

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    1. Roles of the Hedgehog Signaling Pathway in Epidermal and Hair Follicle Development, Homeostasis, and Cancer Journal of developmental biology · 2017 · 72 citations
    2. Disruption of the hedgehog signaling pathway contributes to the hair follicle cycling deficiency in Vdr knockout mice Journal of Cellular Physiology · 2010 · 53 citations
    3. Exosomes Derived From Human Adipose-Derived Stem Cells Inhibit Lipogenesis Involving Hedgehog Signaling Pathway Frontiers in Bioengineering and Biotechnology · 2021 · 13 citations
    4. Roles of the Hedgehog Signaling Pathway in Cutaneous Physiology and Oncology International journal of dermatology and venereology · 2019
    5. Conditional Disruption of Hedgehog Signaling Pathway Defines its Critical Role in Hair Development and Regeneration Journal of Investigative Dermatology · 2000 · 194 citations
    6. Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway Journal of Investigative Dermatology · 2005 · 113 citations
    7. Vitamin E promotes dermal papilla cell proliferation via the lncRNA2919/STAT1 axis to activate the Hedgehog signaling pathway Non-coding RNA Research · 2026
    8. Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways Frontiers in pharmacology · 2018 · 14 citations
    9. Analysis of Sonic Hedgehog signalling pathway gene expression in Basal Cell Carcinoma and in GLII induced systems Queen Mary Research Online (Queen Mary University of London) · 2007
    10. Abstract CN06-04: The hedgehog signaling pathway in cancer. Molecular Cancer Therapeutics · 2011
    11. Aberrant Activation of the Hedgehog Signaling Pathway in Malignant Hematological Neoplasms ˜The œAmerican journal of pathology · 2011 · 68 citations
    12. Mechanism of Targeting the Hedgehog Signaling Pathway against Chemotherapeutic Resistance in Multiple Myeloma Journal of Oncology · 2022 · 5 citations
    13. Targeting sonic hedgehog (shh) signaling pathways by the concentration–dependent topical resveratrol for protection from cyclophosphamide-induced alopecia in a mouse model Toxicology and Applied Pharmacology · 2025
    14. Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours Nature · 1997 · 638 citations
    15. IGFBP5 Promotes Neuronal Apoptosis in a 6-OHDA-Toxicant Model of Parkinson’s Disease by Inhibiting the Sonic Hedgehog Signaling Pathway Medical Principles and Practice · 2024 · 8 citations
    16. Hedgehog signaling is essential for normal wound healing Wound Repair and Regeneration · 2008 · 112 citations
    17. Msi2 Maintains Quiescent State of Hair Follicle Stem Cells by Directly Repressing the Hh Signaling Pathway Journal of Investigative Dermatology · 2017 · 29 citations
    18. Modulating embryonic signaling pathways paves the way for regeneration in wound healing Frontiers in physiology · 2024
    19. Signaling pathways involved in hair follicle cycling and morphogenesis International Journal of Dermatology and Venereology · 2012
    20. Overexpression of Hedgehog Signaling Is Associated with Epidermal Tumor Formation in Vitamin D Receptor–Null Mice Journal of Investigative Dermatology · 2011 · 100 citations
    21. Hes1 regulates anagen initiation and hair follicle regeneration through modulation of hedgehog signaling Stem Cells · 2019 · 20 citations
    22. LncRNA-XIST promotes dermal papilla induced hair follicle regeneration by targeting miR-424 to activate hedgehog signaling Cellular Signalling · 2020 · 11 citations
    23. Hedgehog signalling in skin development and cancer Experimental Dermatology · 2006 · 190 citations
    24. Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state Developmental cell · 2022 · 25 citations
    25. Basal Cell Carcinoma, Hedgehog Signaling, and Targeted Therapeutics: The Long and Winding Road Journal of Investigative Dermatology · 2014 · 15 citations
    26. Molecular Signaling Pathways in Wound-Induced Hair-Follicle Neogenesis Cells · 2025
    27. 1322 A non-cell autonomous dermal hedgehog signaling mechanism for follicular neoplasia and induction Journal of Investigative Dermatology · 2023
    28. Overactivated sonic hedgehog signaling aggravates intrauterine adhesion via inhibiting autophagy in endometrial stromal cells Cell Death and Disease · 2020 · 52 citations
    29. Dermal T cell immunity and key regulatory signaling pathways: Implications in immune-mediated alopecia and hair regeneration Genes & Diseases · 2025 · 1 citations
    30. WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling Experimental & Molecular Medicine · 2021 · 36 citations