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Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Stem cells are crucial for skin repair and new treatments for chronic wounds.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

The ZIP7 gene helps control zinc levels in cells by moving zinc from the Golgi apparatus to the cytoplasm.

Hair follicle development and microbes help regulatory T cells gather in newborn skin.

Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.

Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.

Chemotherapy can cause skin problems like hair loss, mouth sores, and skin darkening, and recognizing these can affect treatment decisions.

Low-Level Laser Therapy is effective and safe for hair growth with minimal side effects.

The peptide GHK-Cu helps heal and remodel tissue, improves skin and hair health, and has potential for treating age-related inflammatory diseases.

Some skin medications are safe during pregnancy and breastfeeding, but others can harm the baby and should be avoided.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

TSH is usually the only test needed to check thyroid function in primary care.

Skin-derived precursors in hair follicles come from different origins but function similarly.

Hair elemental analysis could be useful for health and exposure assessment but requires more standardization and research.

A new gene mutation causes female pseudohermaphroditism due to glucocorticoid resistance.