58 citations,
January 2006 in “Skin Pharmacology and Physiology” High levels of testosterone and 5α-DHT can lead to cell death in cells important for hair growth.
6 citations,
August 2022 in “Science immunology” Foxn1 gene regulation is crucial for thymus development but not for hair growth.
5 citations,
February 2016 in “Sultan Qaboos University medical journal” The patient had a severe itchy rash and hair loss in the armpits.
November 2015 in “Hair transplant forum international” Early attempts at using cloned cells for hair transplants failed, but 3D cell growth showed some promise.
January 2011 in “Reactions Weekly” Long-term use of minoxidil may cause hair follicles to transform into noticeable terminal hairs, leading to trichostasis spinulosa.
July 2022 in “Journal of Investigative Dermatology” TRPS1 loss in balding scalp areas contributes to hair loss in androgenic alopecia.
57 citations,
March 2019 in “Immunity” The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.
47 citations,
May 2012 in “Wiley Interdisciplinary Reviews-Developmental Biology” The conclusion is that understanding how feathers and hairs pattern can help in developing hair regeneration treatments.
28 citations,
November 2020 in “Journal of Controlled Release” A new hair loss treatment uses tiny needles to deliver a drug-loaded lipid carrier, promoting hair growth more effectively than current treatments.
28 citations,
November 2019 in “Gene” The ITGB6 gene is important for tissue repair and hair growth, and mutations can lead to enamel defects and other health issues.
25 citations,
September 2006 in “Birth Defects Research” Different processes create patterns in skin and things like hair and feathers.
21 citations,
October 2017 in “Journal of Investigative Dermatology” The document concludes that understanding dermal papilla cells is key to improving hair regeneration treatments.
3 citations,
March 2010 in “Dermatologica Sinica” A Taiwanese patient had hair loss and skin bumps without the usual gene mutation, suggesting other genetic factors might be involved.
1 citations,
September 2011 in “Journal of Dermatology” A woman with a new PTCH gene mutation has both Gorlin syndrome and severe hair loss.
January 2022 in “Autopsy and Case Reports” A man had a non-cancerous neck tumor related to hair follicles removed with no return of the tumor.
January 2020 in “Medpulse International Journal of General Medicine/Medpulse International Journal of Medicine” Premature graying of hair is often linked with other health issues, but treatment with biotin, zinc, and calcium pantothenate is not very effective.
Different botulinum toxin products and concentrations can effectively reduce sweating, itching, bladder pressure, hair loss, and muscle spasms.
August 2017 in “Journal of Investigative Dermatology” Activin increases skin tumor formation, skin Tregs help hair growth, lymph-node removal doesn't improve melanoma survival, cells can revert to stem cells in wound healing, and skin bacteria produce peptides that may treat infections.
February 2021 in “Journal of Investigative Dermatology” Hair loss in male pattern baldness is linked to changes in specific genes and proteins that affect hair growth and scalp health.
9 citations,
September 2013 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry” Matriptase is highly active in hair follicles and sebaceous glands, especially during hair growth phases.
January 2021 in “Research Square (Research Square)” STAT3 reduces FST gene activity and cell growth, affecting hair development and wool quality.
60 citations,
April 2012 in “Physiology” The document concludes that understanding hair and feather regeneration can help develop new regenerative medicine strategies.
24 citations,
September 2002 in “Dermatologic Surgery” The study found that hair follicles are above muscle connections in the scalp, which may help protect stem cell areas.
211 citations,
February 2009 in “European journal of pharmaceutics and biopharmaceutics” Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.
120 citations,
October 2004 in “International journal of radiation oncology, biology, physics” Higher doses of cranial irradiation are linked to permanent hair loss.
11 citations,
September 2010 in “American Journal of Medical Genetics - Part A” A Turkish family with sparse hair and eyebrow loss has a mutation in the U2HR gene linked to Marie Unna hereditary hypotrichosis.
7 citations,
May 2005 in “Experimental Dermatology” Two mouse mutations cause similar hair loss despite different skin changes.
July 2023 in “Research Square (Research Square)” Skin's uneven surface and hair follicles affect its stress and strain but don't change its overall strength, and help prevent the skin from peeling apart.
1 citations,
December 2022 in “Frontiers in Immunology” Tissue environment greatly affects the unique epigenetic makeup of regulatory T cells, which could impact autoimmune disease treatment.
Hairlessness in mammals is due to complex genetic changes in both genes and regulatory regions.