Fox-Fordyce Disease: A Case Study of a 42-Year-Old Woman

February 2016 in “ Sultan Qaboos University medical journal ”

Gonzalo Blasco‐Morente, M.J. Naranjo-Díaz, Israel Pérez-López, Antonio Martínez‐López, Ricardo Ruiz‐Villaverde, José Aneiros‐Fernández

Fox-Fordyce disease pruritic rash hair loss alopecia follicle-centered papules lymphocytic infiltration sweat glands apocrine gland areas hormonal factors gland obstruction inflammation tretinoin FF rash skin-colored papules gland blockage Retin-A

TLDR The patient had a severe itchy rash and hair loss in the armpits.

A 42-year-old woman presented with severe pruritic rash and hair loss in the axillary regions, diagnosed as Fox-Fordyce disease (FF). Physical examination and dermoscopy revealed skin-colored papules, alopecia, and follicle-centered papules. Histology showed lymphocytic infiltration and obstruction of sweat glands. FF is a rare, chronic condition affecting apocrine gland areas, often triggered by trauma or hormonal factors, leading to gland obstruction and inflammation. Treatment with tretinoin (0.05%) resulted in moderate improvement. FF diagnosis is based on clinical and histopathological features, with various treatments showing limited success.

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