January 1990 in “Springer eBooks” Some chemicals can permanently or temporarily remove color from skin and hair, which can be distressing and is not well-regulated in cosmetics.
January 1983 in “Elsevier eBooks” Cyproterone acetate is used to treat conditions like prostate cancer, early puberty, excessive sexual drive, and female androgenization by affecting androgen functions and suppressing certain hormones.
April 1982 in “Journal of The American Academy of Dermatology” Retinoids help treat psoriasis effectively, but they can cause side effects and need more research on safe use with other treatments.
August 2002 in “Dermatologic Surgery” Fluridil safely promotes hair growth in men with androgenetic alopecia.
January 2024 in “Biochemical and Biophysical Research Communications” Lack of zinc can cause hearing loss by damaging important parts of inner ear cells in mice.
April 2024 in “Frontiers in endocrinology (Lausanne)” Melatonin improved secondary hair growth in goats but didn't affect primary hair density or litter size.
36 citations,
June 2015 in “International journal of toxicology” Trichloroethylene causes skin inflammation in mice by increasing certain immune proteins.
11 citations,
February 2012 in “International journal of pharmaceutics” Ultrasound increases skin permeability but blocks hair follicles.
5 citations,
June 2017 in “in Vivo” Vitamin C deficiency changes gene expression, affecting skin and hair health.
3 citations,
November 2022 in “Experimental dermatology” Melatonin may inhibit melanoma growth and has potential as a cancer therapy aid, but its effects on human skin pigmentation need more research.
April 2024 in “Archives of toxicology” Certain substances can protect against ear damage from some antibiotics in zebrafish.
235 citations,
July 1999 in “Journal of biological chemistry/The Journal of biological chemistry” Human hair is made up of different keratins, some strong and some weak, with specific types appearing at various stages of hair growth.
115 citations,
August 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” Modulating Cytochrome P450 activity could help develop new skin disease treatments.
95 citations,
July 2015 in “European journal of pharmaceutics and biopharmaceutics” Lipid nanoparticles can help deliver drugs through hair follicles but struggle to penetrate deeper skin layers.
86 citations,
May 2002 in “Journal of Investigative Dermatology” A new keratin, hK6irs1, is found in all layers of the hair follicle's inner root sheath.
71 citations,
January 2012 in “PloS one” The conclusion is that genetic differences affect how the cochlea heals after hair cell loss, which may challenge the creation of hearing loss treatments.
53 citations,
January 2013 in “Journal of toxicologic pathology” The project created a standardized system for classifying skin lesions in lab rats and mice.
51 citations,
April 2020 in “Cells” Special cell particles from macrophages can help hair grow.
51 citations,
December 2017 in “Skin Appendage Disorders” Stress may trigger hair loss by affecting immune protection in hair follicles.
51 citations,
January 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” Scientists discovered a unique hair protein, KAP24.1, with a special structure, found only in the upper part of hair cuticles.
48 citations,
November 2002 in “Journal of biological chemistry/The Journal of biological chemistry” Genetic variations in hair keratin proteins exist but don't significantly affect hair structure.
46 citations,
January 2020 in “Research” Microneedle technology has advanced for painless drug delivery and sensitive detection but faces a gap between experimental use and clinical needs.
33 citations,
July 2021 in “Clinical, Cosmetic and Investigational Dermatology” Nanocarrier technology in cosmetics improves ingredient delivery and effectiveness while reducing side effects.
33 citations,
January 2001 in “Critical care clinics” Dietary lipids affect inflammation and are crucial for normal cell function and immune health.
32 citations,
December 2015 in “PloS one” P144® improves hypertrophic scars by reducing size and thickness and increasing elasticity.
31 citations,
July 2021 in “ImmunoTargets and therapy” Alopecia areata is an incurable autoimmune condition causing hair loss, with research aiming for better treatments.
29 citations,
April 2003 in “Experimental dermatology” Human hair follicles grown in vitro maintain normal keratin patterns and structure.
27 citations,
December 2002 in “Journal of dermatological science” Merkel cells and Langerhans cells in hair follicles are closely connected and may interact.
25 citations,
October 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Mouse profilaggrin helps in skin cell differentiation and may be involved in calcium signaling.
20 citations,
June 2022 in “Molecules” Thiazole, a sulfur and nitrogen chemical, is useful in creating potential drugs for conditions like seizures, cancer, bacterial infections, tuberculosis, inflammation, malaria, viruses, Alzheimer's, diabetes, and A1-receptor issues.