research Generalized Glucocorticoid Resistance
Mutations in the glucocorticoid receptor gene cause reduced sensitivity to glucocorticoids and may lead to poor response to treatment.
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research Chrousos Syndrome: From Molecular Pathogenesis to Therapeutic Management
The review suggests thorough evaluation and genetic testing for proper diagnosis and treatment of Chrousos syndrome.
research A Novel Point Mutation in the Ligand-Binding Domain of the Human Glucocorticoid Receptor Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus in Conferring Transactivational Activity
A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.
research Estrogens and Aging Skin
Estrogen therapy can reduce skin aging but has cancer risks.
research Effect of Estrogens on Skin Aging and the Potential Role of SERMs
Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.
research Primary Generalized Glucocorticoid Resistance And Hypersensitivity
The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.
research Androgen Receptor: A Promising Therapeutic Target in Breast Cancer
The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.
research Cytoskeletal Regulation of Dermal Regeneration
Targeting the actin cytoskeleton could improve skin healing and reduce scarring.
research Functional Analysis of VDR Gene Mutation R343H in a Child with Vitamin D-Resistant Rickets with Alopecia
The R343H mutation in the VDR gene causes vitamin D-resistant rickets with alopecia by impairing specific gene activity.
research Vitamin D: More Than a Bona Fide Hormone
Vitamin D is important for bones, hair, blood pressure, and breast development.
research Quantification of the Vitamin D Receptor-Coregulator Interaction
Vitamin D receptor binds similarly to natural and synthetic ligands, affecting gene regulation.
research Androgen Receptors And Their Biology
Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.
research The Nuclear Vitamin D Receptor: Biological and Molecular Regulatory Properties Revealed
The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.
research Recent Advances in the Molecular Mechanisms Determining Tissue Sensitivity to Glucocorticoids: Novel Mutations, Circadian Rhythm, and Ligand-Induced Repression of the Human Glucocorticoid Receptor
New findings explain how genetic changes, body clocks, and certain molecules affect tissue response to stress hormones.
research Recent Advances in the Molecular Mechanisms Causing Primary Generalized Glucocorticoid Resistance
Mutations in the NR3C1 gene cause a rare condition that affects hormone signaling and can lead to various symptoms, with dexamethasone as a treatment option.
research Emerging Medication for the Treatment of Male Hypogonadism
New treatments for male hypogonadism are effective and should be personalized.
research Androgen Effects in Mammals
Testosterone is crucial for development, growth, and various body functions in mammals.
research Human and Animal Cells Under Influence of Different Lighting and Stimuli
Different light affects cell functions and can help treat skin conditions.
research Benefits of Testosterone Replacement and Methods of Substitution
Testosterone replacement therapy helps manage deficiency and has various methods, but requires careful monitoring to avoid side effects.
research Finasteride for Female Androgenetic Alopecia
Finasteride increases hair density in female androgenetic alopecia, but individual results may vary.
research Recent Updates on Wnt Signaling Modulators: A Patent Review (2014-2020)
New patents show progress in developing drugs targeting the Wnt pathway for diseases like cancer and hair loss.
research Androgens and Cardiovascular Disease
Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.
research The Rotterdam Study: 2018 Update on Objectives, Design, and Main Results
The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.
research The Rotterdam Study: 2016 Objectives and Design Update
The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.
research The Rotterdam Study: 2014 Objectives and Design Update
The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.
research The Rotterdam Study: 2012 Objectives and Design Update
The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.
research The Rotterdam Study: 2010 Objectives and Design Update
The Rotterdam Study aims to understand various diseases in older adults.
research Biocompatible Nanoparticles and Vesicular Systems in Transdermal Drug Delivery for Various Skin Diseases
Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.
research Modulation of Glucocorticoid Action and the Treatment of Type-2 Diabetes
Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.
research Steroid Plant Hormones: Effects Outside the Plant Kingdom
Plant steroid hormones show growth, health, and medicinal benefits in various organisms, including potential for treating diseases.