142 citations,
March 2019 in “Frontiers in Cellular Neuroscience” The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.
60 citations,
April 2010 in “General and Comparative Endocrinology” Fadrozole and finasteride change gene expression related to sex hormones and thyroid hormones in frog larvae development.
39 citations,
May 2014 in “Frontiers in Pharmacology” Special immune cells called Tregs can help prevent lung scarring by blocking a specific growth factor.
28 citations,
March 2017 in “Scientific Reports” Minoxidil may protect nerves and improve hair quality during paclitaxel treatment.
3 citations,
October 2010 in “Epilepsy Currents” Altered metabolism can help control seizures by changing brain signaling and energy use, suggesting new treatments for epilepsy.
2 citations,
October 2018 in “Archives of Dermatological Research” Tofacitinib helps mice grow more hair by increasing noggin and BMP4 levels, possibly better than minoxidil.
October 2023 in “Biomedical science and engineering” Innovative methods are reducing animal testing and improving biomedical research.
August 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” Mouse touch-sensitive nerve cells adjust their connections based on competition with other similar cells.
October 2010 in “Epilepsy Currents” Ketogenic diet, neurosteroids, and HMGB1-TLR4 signaling pathway are potential targets for new epilepsy treatments.
222 citations,
October 2014 in “Annual Review of Pharmacology and Toxicology” Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.
218 citations,
December 2011 in “Advances in Urology” The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.
182 citations,
November 2017 in “Molecular Aspects of Medicine” The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.
109 citations,
December 1998 in “The Journal of Dermatology” Manipulating the catagen and telogen phases of hair growth could lead to treatments for hair disorders.
84 citations,
June 2013 in “Stem Cells Translational Medicine” New methods for skin and nerve regeneration can improve healing and feeling after burns.
26 citations,
July 1995 in “Neurobiology of Aging” Finasteride affects prostate weights and pituitary activity differently with age.
19 citations,
December 2019 in “Steroids” Finasteride and dutasteride reduce neurosteroid production, possibly helping treat glioblastoma.
14 citations,
May 2021 in “Marine Drugs” PDRN, derived from salmon sperm, shows promise in healing wounds, reducing inflammation, and regenerating tissues, but more research is needed to understand its mechanisms and improve its use.
13 citations,
March 2012 in “The Journal of Dermatology” Hair transplant surgery can rebuild muscle and nerve connections, allowing transplanted hairs to stand up like normal hairs.
10 citations,
April 2000 in “Archives of Oral Biology” Minocycline may cause hair loss by increasing DHT levels, but finasteride can help counteract this effect.
8 citations,
December 2020 in “The FASEB Journal” Blocking adenosine A2B receptor may prevent or treat hearing loss.
5 citations,
April 2021 in “Biomedicines” The engineered skin substitute helped grow skin with hair on mice.
November 2022 in “CARDIOMETRY” A group has developed therapies that show promise for treating cancer and various other conditions.
January 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” Skin lesions in Carney complex are likely caused by a specific group of skin cells that promote pigment production due to a genetic mutation.
September 2013 in “Science” Transplanted human Olig2+ astroglia may help improve learning and memory after a stroke.
September 2013 in “Science” Human stem cells can aid stroke recovery, research experiences boost students' career aspirations, minoxidil may reduce cancer spread, a molecule can slow tumor growth, a protein affects water flow in cells, magnesium behaves differently at tiny scales, and a new method detects slow-moving objects.
September 2013 in “Science” Undergraduate research experiences boost students' research skills, confidence, and career aspirations.
September 2013 in “Science” Special astrocytes improved learning and memory in rats after a stroke.
September 2013 in “Science” Special astroglia cells improved stroke recovery in rats, a hair growth drug reduced cancer spread, and tiny magnesium structures were more easily shaped.
237 citations,
February 2016 in “Science Translational Medicine” The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.
182 citations,
June 2002 in “Journal of Neuroscience” Androgens can help prevent memory problems caused by apoE4.