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New treatments targeting the Hedgehog pathway can help treat advanced skin cancer but may have side effects and their effectiveness in early stages is unknown.

XIST RNA helps regenerate hair follicles by targeting miR-424 and activating hedgehog signaling.

Different types of fibroblasts play various roles in kidney repair and aging, and may affect chronic kidney disease outcomes.

The combination of azelaic acid, minoxidil, and caffeine significantly increased the survival of skin flaps by affecting certain body channels and nitric oxide levels.

Stopping S100A3 activity slows down hair growth in mice.

The document concluded that stem cells are crucial for skin repair, regeneration, and may help in developing advanced skin substitutes.

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

β-catenin is essential for stem cell activation and proliferation in hair follicles.

Understanding where cancer cells come from helps create better prevention and treatment methods.

Nerves are crucial for the regeneration of various body parts in many animals.

The document concludes that understanding hair follicle biology can lead to better hair loss treatments.

The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.

Lactate production is important for activating hair growth stem cells.

A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.

Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

Different types of stem cells in hair follicles play unique roles in wound healing and hair growth, with some stem cells not originating from existing hair follicles but from non-hair follicle cells. WNT signaling and the Lhx2 factor are key in creating new hair follicles.

Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Potassium channel openers could help treat cardiovascular diseases and asthma but require better targeting to specific tissues for effective use.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.

Activating the Wnt/β-catenin pathway could lead to new hair loss treatments.

Mutant mice help researchers understand hair growth and related genetic factors.

EGF and KGF signalling prevent hair follicle formation and promote skin cell development in mice.