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The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.

Nestin-expressing cells turn into a specific type of skin cell in hair follicles during development and in adults.

Nestin marks cells that can become a specific type of skin cell in hair follicles of both developing and adult mice.

Two-photon microscopy effectively tracks live stem cell activity in mouse skin with minimal harm and clear images.

The circadian clock affects skin stem cell behavior, impacting aging and cancer risk.

Skin lymphatic vessels are essential for hair growth.

Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

Inflammation plays a key role in activating skin stem cells for hair growth and wound healing, but more research is needed to understand how it directs cell behavior.

Blocking TSLP reduces skin inflammation and cell overgrowth in psoriasis.

Genetically modified sheep with more β-catenin grew more wool without changing the wool's length or thickness.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

The protein SLC1A3 is important for activating skin stem cells and is necessary for normal hair and skin growth in mice.

The review found that different stem cell types in the skin are crucial for repair and could help treat skin diseases and cancer.

Stem cell differentiation is crucial for skin barrier maintenance and its disruption can lead to skin diseases.

Stem cells help heal skin wounds by moving and changing roles, working with other cells, and needing more research on their activation and behavior.

Different stem cells have benefits and challenges for tissue repair, and more research is needed to find the best types for each use.

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.

Hair follicles are essential for skin health, aiding in hair growth, wound healing, and immune function.

The guide explains how to study human skin fat cells and their tissue, aiming to improve research and medical treatments.

Gene network oscillations inside hair stem cells are key for hair growth regulation and could help treat hair loss.

Bioluminescence imaging can track hair follicle cells and help study hair regrowth.

New treatments for skin and hair repair show promise, but further improvements are needed.

PDGF signaling is crucial for maintaining and renewing hair follicle stem cells, which could help treat hair loss.

MicroRNAs are important for skin health and could be targets for new skin disorder treatments.

Hormone imbalances can cause skin diseases, and understanding these links is important for diagnosis and treatment.

Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.

Special proteins are important for skin balance, healing, and aging, and affect skin stem cells.

Mast cells likely promote skin scarring and fibrosis, but their exact role is still unclear.

Certain proteins, caspases-1 and -11, are important in the early development of skin inflammation in mice.