August 2023 in “Military Medical Research” Scientists have improved 3D models of human skin for research and medical uses, but still face challenges in perfectly replicating real skin.
January 2023 in “Dermatologic Therapy” A new hand-held light therapy device was found to be safe and effective for treating mild-to-moderate acne.
January 2023 in “Skin appendage disorders” Low-dose oral minoxidil may help treat hair loss but is not FDA-approved and can cause side effects like unwanted hair growth and heart issues.
December 2022 in “Dermatology and Therapy” Alopecia areata needs more recognition and better treatment access in Latin America to improve patient care and outcomes.
May 2024 in “Proteome science” Bleaching damages hair by reducing the quality of keratin and keratin-associated proteins.
1 citations,
January 2020 in “Recent Research in Genetics and Genomics/Recent Research in Genetics and Genomics ” High doses of Lepidium sativum seed extract are toxic and should be used with caution.
14 citations,
March 1995 in “Journal of cell science” SV40 T antigen in hair follicles causes abnormal hair and health issues in mice.
66 citations,
December 2013 in “Nature Cell Biology” Inactive hair follicle stem cells help prevent skin cancer.
14 citations,
February 2018 in “Psychoneuroendocrinology” Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.
January 2014 in “Journal of Investigative Dermatology” Proteins like aPKC and PDGF-AA, substances like adenosine and ATP, and adipose-derived stem cells all play important roles in hair growth and health, and could potentially be used to treat hair loss and skin conditions.
September 2013 in “Molecular Biology” The document suggests that activating autophagy might help with regeneration by removing old and damaged cells.
57 citations,
January 2014 in “Cold Spring Harbor Perspectives in Medicine” Skin stem cells maintain and repair the outer layer of skin, with some types being essential for healing wounds.
52 citations,
April 2013 in “Developmental Cell” Brg1 is crucial for hair growth and skin repair by maintaining stem cells and promoting regeneration.
129 citations,
May 2015 in “Cell Stem Cell” Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.
Activin A and follistatin control when ear hair cells form in mice.
31 citations,
April 2016 in “Nature communications” Certain signals are important for reducing specific chemical markers on hair follicle stem cells during rest periods, which is necessary for healthy hair growth.
133 citations,
September 2013 in “Nature Reviews Molecular Cell Biology” Different types of stem cells and their environments are key to skin repair and maintenance.
106 citations,
March 2014 in “BioEssays” We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.
80 citations,
May 2011 in “Nature Cell Biology” New methods have greatly improved our understanding of stem cell behavior and roles in the body.
291 citations,
October 2005 in “Proceedings of the National Academy of Sciences of the United States of America” Adult stem cells from rat whisker follicles can regenerate hair follicles and sebaceous glands.
151 citations,
July 2011 in “Archives of Dermatological Research” Liposomal systems show promise for delivering drugs through the skin but face challenges like high costs and stability issues.
150 citations,
December 2012 in “EMBO Reports” Stem cell self-renewal is complex and needs more research for full understanding.
113 citations,
June 2015 in “Stem Cell Research & Therapy” Wnt and Notch signaling help wound healing by promoting cell growth and regulating cell differentiation.
17 citations,
June 2012 in “Journal of experimental zoology. Part B, Molecular and developmental evolution” Hair in mammals likely evolved from glandular structures, not scales.
12 citations,
November 2020 in “Journal of Dermatological Science” Found microRNA differences in hair cells, suggesting potential treatment targets for hair loss.
3 citations,
January 2020 in “Plastic and Aesthetic Research” Non-surgical procedures can help reduce wrinkles and stimulate skin repair by understanding skin aging at the molecular level.
Activin A promotes ear hair cell development, while follistatin delays it.
CRISPR/Cas9 gene-editing shows promise for livestock breeding but faces challenges like low efficiency and off-target effects.
12 citations,
January 2021 in “International Journal of Biological Sciences” Scientists successfully edited a goat's genes to grow more and longer cashmere hair.
December 2023 in “Frontiers in plant physiology” Root hairs are key for developing cereals that can fertilize themselves with nitrogen.