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Gender-affirming hormone therapy affects metabolism differently based on treatment type.

Future hormone therapy trials should match the diverse needs and priorities of the gender-diverse community.

The document concludes that gender-affirming treatments are essential for transgender individuals and outlines safe hormone therapy practices.

The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Gender-affirming therapy can cause skin issues like acne and hair loss in transgender adolescents, and more research is needed on its dermatological effects.

More research is needed on the health effects of hormone therapy for transgender and nonbinary people.

Parental support and gender-affirming care are crucial for the mental health of transgender adolescents.

Transgender patients need proper skin care, especially when undergoing hormone treatments, to manage issues like acne and hair loss.

Gender-affirming care for youth remained essential during the COVID-19 pandemic, with telemedicine playing a key role.

Testosterone therapy seems safe and effective for transgender men with proper care, but more long-term research is needed.

Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.

Topical minoxidil helps transgender individuals assigned female at birth grow more facial hair.

Gender-affirming hormone therapy improves physical performance in trans men to the level of cisgender men, while in trans women, it increases fat mass and decreases muscle mass, with no advantage in physical performance after 2 years.

Hormone therapy increases the risk of heart-related issues in transgender women and may affect heart health in transgender men.

Adults with gender dysphoria on hormone treatment often have skin problems like acne, which are common but not always recognized.

The safety and effectiveness of gender-affirming treatments for children are uncertain, with potential long-term risks like infertility.

Early medical support for transgender youth is important for their health, with low regret for gender-affirming hormone use and a need for knowledgeable care providers.

The document advises health care providers on how to support transgender and gender-diverse youth with appropriate care and referrals.

Testosterone treatment effectively causes male physical development in transgender male adolescents but may lead to side effects like acne, higher BMI and blood pressure, lower good cholesterol, and decreased bone density.

Many children and teens referred to gender services receive hormone treatments, but more research is needed on their long-term care and outcomes.

Inclusive and affirming healthcare is essential for improving transgender individuals' quality of life and health.

The document concludes that personalized hormonal treatments are important for transgender individuals and more research is needed for non-binary treatments.

Transgender patients in critical care need better-trained medical staff and specific guidelines.

Hormone treatment for transgender patients may not need to be stopped before surgery, but more research is needed, especially on estrogen.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Australian doctors experienced in adult transgender healthcare mostly prescribe intramuscular testosterone and oral estradiol, recommend mental health assessments before hormone therapy, and support improved training and guidelines.

Hormone therapy improves mental well-being in transgender individuals but requires ongoing health monitoring.

Dihydrotestosterone makes arteries stiffer in female mice by reducing estrogen receptor expression.

Testosterone therapy for transmasculine individuals is generally safe with medical supervision, improves mental health, and has mixed effects on physical health.

Sex hormones' effects on COVID-19 are unclear and more research is needed to understand their potential as treatment.