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Glossary Gender Dysphoria

feeling distress due to a mismatch between gender identity and assigned sex

Gender Dysphoria is a psychological condition where an individual experiences significant distress or discomfort because their gender identity does not align with their assigned sex at birth. This condition, also known as gender incongruence, can lead to emotional and mental health challenges, and often requires a combination of psychological support, social transition, and sometimes medical interventions to alleviate the distress.

Related Terms

Research

5 / 1000+ results

research Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society* Clinical Practice Guideline

2170 citations , September 2017 in “The Journal of Clinical Endocrinology & Metabolism”

This updated guideline from the Endocrine Society highlights the importance of endocrinologists in providing safe and effective hormone regimens for gender-affirming care, especially for adolescents who have entered puberty.

research Cross-sex hormone therapy for gender dysphoria

21 citations , November 2014 in “Journal of Endocrinological Investigation”

This review discusses cross-sex hormone therapy for managing gender dysphoria in transsexual individuals and reports no new clinical results; it highlights the need for education and culturally sensitive training for healthcare professionals.

research Evaluation and Treatment of Gender Dysphoria to Prepare for Gender Confirmation Surgery

17 citations , June 2018 in “Sexual Medicine Reviews”

In this review, the authors examined guidelines and literature on the non-operative treatment of gender dysphoria, highlighting the importance of personalized, multidisciplinary care, and noting that such treatment is generally safe and effective according to WPATH and Endocrine Society recommendations.

Medical Care for Children and Adolescents with Gender Dysphoria and Gender Inconsistency in Light of Current Recommendations: How to Implement the 'Primum Non Nocere' Principle?

research Medical care for children and adolescents with gender dysphoria and gender inconsistency in the light of current recommendations - how to implement the "primum non nocere" principle?

September 2023 in “Fides et Ratio”

This paper reviews the current lack of evidence on the safety and effectiveness of gender-affirming therapies in minors with gender dysphoria, highlighting ethical and legal concerns, including possible long-term consequences such as infertility.

research Endocrine Management of Adult Gender-Dysphoric/Gender-Incongruent Persons: A Clinical Practice Guideline from Endocrine Society of India

July 2025 in “Indian Journal of Endocrinology and Metabolism”

This source provides a comprehensive guideline for the management of transgender individuals in India, highlighting the need for multidisciplinary diagnosis, counseling for gender-affirming hormone therapy, and the importance of addressing social stigma, legal issues, and medical training to improve healthcare access for this population.

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Community Join

5 / 142 results

community Guaranteed Way to Revive ALL Follicles. Transition, and then Transition Back & Maintain (for Men)

250 upvotes 1 year ago

Transitioning genders humorously suggested for hair regrowth, noting some transgender individuals experience this. Discusses treatments like minoxidil, finasteride, and hormone therapy, but advises against transitioning solely for hair regrowth.

community Sorry yall I cheated 😵‍💫 1 year fin + hrt

682 upvotes 9 months ago

Hair regrowth and gender transition using finasteride, estrogen, and spironolactone. Significant hair regrowth and personal transformation were achieved through hormone replacement therapy.

community I don’t understand this, is he equating taking Fin with being on HRT?

303 upvotes 1 year ago

The conversation is about using finasteride and testosterone replacement therapy (TRT) for hair loss and their role in gender-affirming care. It debates whether these treatments are considered hormone replacement therapy (HRT) and their implications for both cisgender and transgender individuals.

community Yet another hrt update (4 months estradiol and spiro + > 4 years of fin and min) (you should absolutely not take estradiol and spiro if you look manly and want to continue to look manly)

4 upvotes 1 year ago

The conversation discusses hair loss treatments, including finasteride, minoxidil, estradiol, and spironolactone, with a focus on their effects on hair regrowth and gender transition. The original poster shares their personal experience with these treatments, emphasizing that estradiol and spironolactone should not be used by those who want to maintain a masculine appearance.

community (MTF 35) Results of 18 Months of HRT

775 upvotes 8 months ago

A transgender woman experienced significant hair regrowth after 18 months of hormone replacement therapy (HRT) with estrogen and bicalutamide. The discussion notes HRT's effectiveness for hair regrowth but warns against its use for cisgender men due to feminizing effects.

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Learn

3 / 801 results

learn Cyproterone

Is cyproterone safe to use during gender transition? Regulators and a large French cohort study link higher-dose, long-term cyproterone acetate to meningioma, and its label also lists liver-enzyme and mood effects — so it is not a drug anyone should call safe in the abstract, and its use in gender-affirming care is a prescriber's decision with monitoring.

learn Clascoterone

Can I use clascoterone if I'm undergoing gender-affirming hormone therapy? No published clinical trial has tested clascoterone in people on gender-affirming hormone therapy, so its safety in that group is unknown. The FDA label reports low systemic exposure and no described effect on blood testosterone, but it also records HPA-axis suppression and raised potassium in a small minority of subjects.

learn Setipiprant

Can Setipiprant be used safely by women or people undergoing gender transition? Setipiprant's safety for women and those in transition is not well-studied.

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