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Stem cell self-renewal is complex and needs more research for full understanding.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Platelet-rich plasma might help with hair growth and skin conditions, but more research is needed to prove its effectiveness and safety.

Potassium channel openers could help treat cardiovascular diseases and asthma but require better targeting to specific tissues for effective use.

The AUTS2 gene is linked to neurological disorders and may affect human brain development and cognition.

Minoxidil effectively treats hair loss, but use cautiously and monitor side effects.

PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.

Treating psoriasis on the scalp, nails, and skin folds is challenging, often requiring systemic treatments for severe cases, with some success in topical and biologic treatments.

Hair elemental analysis could be useful for health and exposure assessment but requires more standardization and research.

Ozone reacts more with unwashed hair, producing compounds due to scalp oils, which could lower ozone exposure but increase exposure to reaction products.

Researchers identified genes linked to coat color, body size, cashmere production, and high altitude adaptation in goats.

The circadian clock is crucial for tissue renewal and regeneration, affecting stem cell functions and having implications for health and disease.

Low-oxygen conditions and ECM degradation products increase the healing abilities of perivascular stem cells.

The Wnt/β-catenin pathway is important for tissue development and has potential in regenerative medicine, but requires more research for therapeutic use.

Exosomes from dermal papilla cells can help grow hair and might treat hair loss.

The document concludes that diagnosing and treating Human African Trypanosomiasis is challenging, but new treatments like fexinidazole are promising.

Mammals might fail to regenerate not because they lack the right cells, but because of how cells respond to their surroundings, and changing this environment could enhance regeneration.

Keratin 15 is not a reliable sole marker for identifying epidermal stem cells because it's found in various cell types.

Sponge helps heal wounds faster with less inflammation and better skin/hair growth.

A certain smell receptor in hair follicles can affect hair growth when activated by a synthetic sandalwood scent.

Platelet-rich plasma may have some benefits in dermatology, but there's not enough evidence to widely recommend its use.

The circadian clock influences the behavior and regeneration of stem cells in the body.

Four genetic risk spots found for hair loss, with WNT signaling involved and a link to curly hair.

Prolactin affects when mice shed and grow hair.

mTOR signaling helps activate hair stem cells by balancing out the suppression caused by BMP during hair growth.

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.

A deficiency in the TTC7A gene causes immune problems, gut issues, and hair loss.

Prolactin affects the production of different keratins in human hair, which could lead to new treatments for skin and hair disorders.