Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that bikunin is expressed in human keratinocytes and may play a role in regulating keratinocyte function during mitosis or inflammation.

In this study, researchers analyzed skin tumors from patients with CYLD cutaneous syndrome and found that loss of CYLD function is linked to changes in cellular signaling pathways, particularly NF-κB signaling, and leads to increased secretion of specific extracellular matrix proteins.

Different keratin proteins are expressed in various epithelial cells at different stages, affecting cell structure and function.

In this study, methanol extract of Cuscuta reflexa leaves significantly reduced blood glucose and improved insulin and liver function in alloxan-induced diabetic rats, indicating potential as an antidiabetic and organ-protective agent.

In this study, bezafibrate treatment improved certain aging-like features in a mouse model with mitochondrial dysfunction, but did not enhance muscle function or lifespan.

In this study, conditional deletion of BRD4 in OX40-expressing cells of mice led to alopecia, dermatitis, and loss of hair follicle stem cell function, revealing BRD4's role in skin inflammation and stem cell regulation.

In this study, researchers reported that treating alopecia areata patients with ritlecitinib led to progressive improvements in emotional symptoms and activity limitations over 48 weeks, though the post hoc analysis and trial setting suggest caution in interpreting the findings for broader populations.

This study identified a high proportion of dual TCR Treg cells in both lymphoid and non-lymphoid tissues of mice, revealing their tissue specificity, TCR repertoire characteristics, and functional phenotypes.

This study identified 193 plasma proteins associated with prostate cancer risk, validating 20 high-risk proteins including KLK3, and pinpointed potential drug targets like HSPB1, RRM2B, and PSCA through genetic analysis, offering new insights for biomarkers and treatments.

This study reported that interdisciplinary treatment, combining surgical and rehabilitation methods, led to satisfactory outcomes for patients with extensive facial skull injuries. The authors emphasized the importance of teamwork between surgeons and physiotherapists to minimize complications and enhance recovery, restoring function, aesthetics, and physical fitness.

This study found that neonatal Regulatory T cells are crucial for maintaining PPARγ signaling in hair follicles, which supports melanocyte stem cell function and skin pigmentation during early postnatal development.

This study identified non-structural proteins in preschool children's scalp hair that suggest potential biomarkers for brain development, immune function, and stress response with heritability and age-related differences.

This study suggests that the expression of VLCFA biosynthesis genes is suppressed in skin hyperplasia and cancer, which could influence keratinocyte function.

This study found that the E6 gene, but not E7, was responsible for HPV8-induced expansion of keratinocyte stem cells in hair follicle junctional zones in mice.

This case report describes the characteristic clinicopathological features of trichodysplasia spinulosa in two boys with acute lymphocytic leukemia, highlighting its resolution as immune function normalizes.

In this study, treating refractory alopecia universalis with low-dose cyclosporine A and prednisolone improved symptoms, with no recurring alopecia six months post-treatment and enhancements in immunologic function.

This report examines the cautious approach to administering live vaccines to an infant with a heterozygous FOXN1 variant, noting the importance of monitoring TREC levels and immune function indicators in guiding vaccination decisions in such cases.

This study found that high levels of μ-crystallin in skeletal muscle are associated with greater fat metabolism and a shift in gene expression towards slower muscle function.

This study assesses the potential of exosomes as a therapeutic option for androgenetic alopecia, examining their mechanisms and effectiveness. The authors conducted a systematic review of existing research to explore how these extracellular vesicles might stimulate hair growth and restore follicle function.

In this research, the authors identify coordinated mechanical forces as crucial for hair follicle development in mammals, with contractile, proliferative, and proteolytic activities facilitating the formation and sectioning of epithelial structures crucial for forming a functional tissue.

This study identified that Mangkokan leaf extracts contain active compounds such as alkaloids, flavonoids, steroids, tannins, phenols, and saponins, using different solvents and FTIR analysis.

This review highlights capsaicin's chemical properties, natural sources, and its potential benefits such as antioxidant, anti-inflammatory, and analgesic effects, while also noting its challenges in food applications regarding dosage, taste perception, and regulatory compliance.

This study found that BRG1 is crucial for keratinocyte migration during skin wound healing, as its suppression impairs wound closure by inhibiting migration without affecting cell proliferation or apoptosis.

This study characterizes gene expression patterns in embryonic hair follicle progenitors and their niche, identifying signaling pathways like axon guidance that may drive cellular rearrangements for hair follicle formation.

This article discusses the mechanisms and prevention of aging, particularly in facial rejuvenation, but reports no new experimental findings.

This review identified significant effects of photobiomodulation therapy on pain reduction in burning mouth syndrome, disability in knee osteoarthritis, and fatigue in fibromyalgia, but noted that most outcomes had low-to-moderate certainty of evidence, indicating a need for further high-quality trials.

This study revealed that metformin, beyond its hypoglycemic use, may have potential reuse in treating obesity, cardio-cerebrovascular diseases, and more, including possible future applications for Alzheimer's and other conditions.

This review discusses the development and advances in studying trichogenic dermal cells for hair follicle morphogenesis, summarizing methods, bioassays, and molecular markers, but reports no new research findings.

This review discusses advanced techniques for investigating stem cell fate at the single-cell level, including lineage tracing, time-lapse imaging, and molecular profiling, but reports no new research results.

This study found genetic variations, including de novo variants and copy number variations, that may be associated with phenotypic discordance in monozygotic twins with various clinical conditions.