Decision-Making Regarding the Administration of Live Vaccines to Patients With a FOXN1 Heterozygous Missense Variant

    January 2026 in “ Pediatrics International ”
    Motoko Yasutomi, Yuko Isozaki, Takashi Okuno … Yusei Ohshima
    Studysummary This report examines the cautious approach to administering live vaccines to an infant with a heterozygous FOXN1 variant, noting the importance of monitoring TREC levels and immune function indicators in guiding vaccination decisions in such cases.
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    Research cited in this study 2

    1. Expanding the Nude SCID/CID Phenotype Associated with FOXN1 Homozygous, Compound Heterozygous, or Heterozygous Mutations Journal of Clinical Immunology · 2021
    2. Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis American journal of human genetics · 2019