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research 1465 Optimization/characterization of a Focal Dermal Hypoplasia mouse model to test potential treatments
This study found that in a mouse model of Focal Dermal Hypoplasia, treatment with lithium carbonate improved skin disease symptoms compared to controls, though disease severity varied and posed interpretation challenges.
research KATP Channels in Zebrafish Cardiovascular System: A Model to Study Cantú Syndrome
This study confirms that zebrafish engineered with Cantú Syndrome mutations in ABCC9 and KCNJ8 genes exhibit gain-of-function characteristics in their cardiovascular KATP channels, similar to mammalian counterparts.
research Bio-Catalytic Action of Pseudomonas DL17 on Environmental Contaminant Sunset Yellow FCF
This study found that Pseudomonas DL7 completely degraded 600 mg/L of Sunset Yellow FCF in 48 hours at pH 9, indicating potential for biomineralization of this dye.
research Formulation-by-Design of Efinaconazole Spanlastic Nanovesicles for Transungual Delivery Using Statistical Risk Management and Multivariate Analytical Techniques
This study optimized efinaconazole spanlastic nanovesicles using risk management and multivariate analysis for potential transungual delivery to treat onychomycosis, achieving improved drug permeability and dissolution efficiency.
research Determination of vinflunine in Beagle dog′s plasma by LC-MS and study of its pharmacokinetics
This study established a simple and accurate LC-MS method for quantifying vinflunine in Beagle dog plasma, supporting pharmacokinetic research in this context.
research Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion
This study found that dysregulation of the folliculin-p0071 interaction may lead to changes in cell adhesion and signaling, contributing to conditions like emphysema and renal cell carcinoma.
research Diffusion properties of model compounds in artificial sebum
This study found that drug transport through artificial sebum varies depending on the compound, suggesting that sebum-targeted delivery can be optimized by selecting compounds based on their distinct transport profiles in sebum versus skin.
research Dodatek A: Model matematyczny AL/RC/ASE. Functional Androgen Axis (FOA) - wersja operacyjna v1.2
This research presents the Dodatek A model, elaborating on androgen function through new mathematical indices and methodological improvements, shifting focus from serum hormone concentrations to system interactions to better describe androgen activity comprehensively.
research Rapidly progressing mycosis fungoides presenting as follicular mucinosis
This case report indicates that follicular mucinosis can be an early sign of rapidly progressing mycosis fungoides, particularly with the aggressive folliculotropic variant.
research Expanding the Nude SCID/CID Phenotype Associated with FOXN1 Homozygous, Compound Heterozygous, or Heterozygous Mutations
This study describes various clinical phenotypes associated with FOXN1 mutations, finding that affected individuals may develop different severities of immunodeficiency based on their genetic mutations.
research 2′‐Fucosyllactose Alleviates Hair Loss in Testosterone‐Induced Androgenic Alopecia Mice
In this study, 2′‐Fucosyllactose (2′‐FL) administration significantly reduced hair loss and increased hair length and thickness in a testosterone-induced androgenic alopecia mouse model, suggesting potential as a therapeutic agent for AGA.
research Hague (Hag): A New Mouse Hair Mutation With an Unstable Semidominant Allele
This study mapped a spontaneous mouse hair mutation, "hague," to keratin genes on chromosome 15 but found no gene mutations in hague mice.
research Folate-cyclodextrin Conjugate for Targeted Chemotherapy
This study tested a folate-conjugate drug delivery system and found its cytotoxicity depends on whether the treated cells overexpress folate receptors, suggesting potential for targeted chemotherapy.
research Study of some pharmacotechnological, physico-chemical and pharmacognostic properties of common fennel (Foeniculum vulgare) fruit
This study examined the technological characteristics of Foeniculum vulgare fruits, widely available in Ukraine, to optimize drug production aimed at improving digestion and gastrointestinal function, highlighting parameters like extractive efficiency and raw material properties essential for manufacturing.
research A Fluorescence-based Lymphocyte Assay Suitable for High-throughput Screening of Small Molecules
This study introduced a novel in vitro murine assay using transgenic mice to identify immunomodulatory compounds, which identified 160 potential hits from 4,398 compounds screened.
research Colourless side of the nude mutation: Foxn1 and hair pigmentation
This study suggests that Foxn1 expression in keratinocytes influences pigmentation in mice, highlighting differences in the molecular mechanisms between mouse and human pigmentation processes.
research MLO‐mediated Ca2+ influx regulates root hair tip growth in Arabidopsis
This study demonstrated that the FER/MLO signaling module regulates calcium dynamics and ROS accumulation in root hair growth, with the constitutively active MLO (faNTA) able to restore normal development and signaling in specific mutant genotypes, highlighting MLO15's role in root hair tip growth regulation.
research The long and the short of it: evidence that FGF5 is a major determinant of canine ‘hair’‐itability
This study found that a missense mutation in the FGF5 gene is associated with hair-length differences among various dog breeds.
research Antidepressant-like effect of fluoxetine may depend on translocator protein activity and pretest session duration in forced swimming test in mice
This study found that the antidepressant-like effect of fluoxetine in mice was only observed when a 5-minute pretest session was conducted, and this effect was blocked by the TSPO antagonist PK11195.
research Analysis of hair follicle penetration of lidocaine and fluorescein isothiocyanate-dextran 4 kDa using hair follicle-plugging method
This study highlights the significance of the hf pathway for the skin permeation of ionized and hydrophilic high molecular compounds, and the usefulness of hf-plugging in evaluating their skin permeability.
research The feasibility and utility of hair follicle sampling to measure FMRP and FMR1 mRNA in children with or without fragile X syndrome: a pilot study
This study observed that repeated hair follicle sampling is feasible and reliable for measuring FMR1 mRNA and FMRP in individuals with Fragile X syndrome, supporting its use in longitudinal studies.
research MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial and ciliary functions by controlling gene promoters
This study found that deleting the Mof gene in mouse skin leads to severe defects in skin cell self-renewal, differentiation, and hair follicle growth, indicating that MOF is crucial for mitochondrial and ciliary gene expression and essential for skin development.
research CRISPR/Cas9-mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen
This study found that FGF5-/- rabbits exhibited a significant long hair phenotype by prolonging the anagen phase, suggesting FGF5 acts as a negative regulator of hair growth.
research Assessment the Effect of Ficus carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3 & Caspase-9 on Induction of Intrinsic Apoptosis Cascade
This study found that methanolic extract of Ficus carica leaves induced apoptosis and inhibited proliferation in B16F10 melanoma cells, suggesting potential anti-cancer properties for further investigation in melanoma.
research Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production
In this study, knockout mice lacking the Cyp4f39 gene showed severe skin barrier dysfunction and high early mortality, suggesting its critical role in skin barrier formation and insights into ichthyosis pathogenesis.
research Slug (Snai2) Expression during Skin and Hair Follicle Development
Slug (Snai2) helps regulate hair growth timing in mice.
research Optimization and Characterization of Cuscuta reflexa Extract Loaded Phytosomes by the Box-Behnken Design to Improve the Oral Bioavailability
This study found that a phytosomal delivery system improved the bioavailability of Cuscuta reflexa extract compared to the plain extract, suggesting enhanced potential for this formulation.
research Inhibitory Effect of Fermented Flammulina velutipes Polysaccharides on Mice Intestinal Inflammation
This study found that fermented Flammulina velutipes polysaccharides showed higher antioxidant and anti-inflammatory capacities than non-fermented ones, suggesting potential use in functional foods and health products.
research PROFILING KEY METABOLITES IN SHALLOT UNDER FUSARIUM INFECTION
Infected shallots have more diverse metabolites, with certain compounds indicating resistance to Fusarium disease.