October 2015 in “Elsevier eBooks” Pramipexole can cause side effects like dizziness, sleepiness, hallucinations, and low blood pressure, and it's important to educate patients and keep doses low.
January 2026 in “Frontiers in Medicine” This article questions whether frontal fibrosing alopecia and fibrosing androgeneic patterned hair loss are overlapping conditions or stages of the same process, calling for further research to clarify their underlying factors.
May 2022 in “Endocrine Abstracts” Finasteride may cause sexual dysfunction by reducing epinephrine levels.
July 2018 in “Elsevier eBooks” This review discusses the evolving understanding of frontal fibrosing alopecia as a generalized skin condition with diverse manifestations, and reports no new clinical results.
March 2023 in “Archives of Physical Medicine and Rehabilitation” This pilot study suggests that high-dose testosterone plus finasteride improved body composition in men with impaired gait and low to low-normal testosterone after chronic incomplete spinal cord injury.
March 2025 in “Journal of Clinical Medicine” This review discusses the unique clinical features, challenges in diagnosis, and treatment protocols of frontal fibrosing alopecia in men, noting the overlap with other types of alopecia and the need for further studies.
November 2024 in “Dermatology and Therapy” In this review, cosmetic practices such as non-ablative lasers, autologous fat injections, and oral isotretinoin may help alleviate certain symptoms of frontal fibrosing alopecia, while treatments like deep chemical peels and ablative laser therapies are contraindicated due to potential scarring risks.
1 citations
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January 2013 in “Digital Scholarship - UNLV (University of Nevada Reno)” This study hypothesized that finasteride administration may increase stress-induced amphetamine locomotor sensitization due to its impact on brain reward systems involving the neurosteroid allopregnanolone.
March 2023 in “Archives of Physical Medicine and Rehabilitation” This pilot study suggests that high-dose testosterone plus finasteride improved knee extensor strength and muscle size in men with impaired gait after chronic incomplete spinal cord injury.
25 citations
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June 2017 in “Scientific reports” This study suggests that stress may worsen Tourette syndrome symptoms in mice by increasing allopregnanolone synthesis, with findings supporting finasteride as a potential treatment to manage symptom fluctuations.
September 2017 in “Journal of Investigative Dermatology” This study found that certain circulating miRNAs in skin and plasma may serve as potential biomarkers for distinguishing frontal fibrosing alopecia from control cases, highlighting the need for further validation in larger cohorts.
2 citations
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January 2023 in “Pharmaceuticals” This study found that in male mice, microglial changes due to a Parkinson's-like lesion were influenced by sex hormones, with dutasteride treatment preventing some effects.
23 citations
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November 2018 in “Journal of the European Academy of Dermatology and Venereology” This study observed that frontal fibrosing alopecia is increasingly diagnosed in Italian Caucasian females, often showing premenopausal onset and eyebrow alopecia as an early sign.
March 2025 in “Revista Foco” This review describes the clinical signs, symptoms, and diagnostic findings for alopecia frontal fibrosante, emphasizing the importance of early diagnosis and variable treatment options, and reports no new findings.
January 2016 in “Indian dermatology online journal” This case study diagnosed a 60-year-old woman with frontal fibrosing alopecia after histopathological analysis showed characteristic scarring patterns in the hairline area.
July 2023 in “World Journal of Biology Pharmacy and Health Sciences” This research suggests that the drugs trazodone and chlorpromazine, which have effects on specific receptors, may help restore libido synaptic circuits and potentially treat sexual dysfunction associated with post-SSRI and post-finasteride syndromes.
6 citations
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January 2019 in “Medical Hypotheses” This hypothesis article explores frontal fibrosing alopecia as a potential autoimmune condition and calls for future research to investigate this possibility, but reports no new clinical results.
17 citations
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October 2017 in “Journal of Cutaneous Medicine and Surgery” This review discusses the various treatment options for frontal fibrosing alopecia but reports no definitive results, as no treatment has proven effective in halting hairline recession or promoting hair growth.
21 citations
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April 2016 in “Journal of Dermatological Treatment” This paper discusses the potential relationship between finasteride's adverse effects and factors like hand preference and sexual orientation, suggesting these could influence risk in male androgenic alopecia treatment, but reports no new clinical results.
April 2025 in “Australasian Journal of Dermatology” This report presents the first Australian case of familial frontal fibrosing alopecia involving a mother and daughter and seeks to differentiate clinical features between familial and sporadic cases.
8 citations
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January 2002 in “Piel” Postmenopausal women may experience frontal hairline and eyebrow loss due to cicatricial fibrosis.
In this study, lower dihydrotestosterone and higher testosterone levels were linked to increased brain activation during response inhibition, although no behavioral changes were detected.
9 citations
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January 2018 in “Journal of the European Academy of Dermatology and Venereology” A male patient developed frontal fibrosing alopecia after antiandrogen therapy for prostate cancer.
This study found that patients with frontal fibrosing alopecia showed significant alterations in protein expression in forehead corneocytes, suggesting the condition may have systemic implications beyond the scalp.
36 citations
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December 2017 in “Journal of the American Academy of Dermatology” This study observed that 70.7% of patients with frontal fibrosing alopecia stabilized with treatment, and patients using 0.3% tacrolimus were more likely to stabilize in 3 months compared to other treatments.
May 2026 in “The Journal of Headache and Pain” In this study, researchers developed an enhanced rodent model of trigeminal neuralgia, demonstrating that structural and functional changes in the anterior cingulate cortex are linked to chronic pain and emotional disturbances, and chemogenetic inhibition of specific neurons could alleviate symptoms.
September 2024 in “Journal of the American Academy of Dermatology” Seborrheic dermatitis affects quality of life and sleep, linked to stress and nervous system changes.
332 citations
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June 1994 in “Archives of Dermatology” This study found that progressive frontal hairline recession in postmenopausal women may exhibit features similar to fibrosing alopecia, with histologic similarities to lichen planopilaris but lacking lesions of lichen planus.
68 citations
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May 2016 in “Experimental dermatology” This review discusses what is known about the pathobiology of frontal fibrosing alopecia and reports no new clinical findings, highlighting potential environmental and genetic factors in disease pathogenesis.
34 citations
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June 2020 in “British journal of dermatology/British journal of dermatology, Supplement” In this study, researchers observed that follicular damage and stem cell loss in frontal fibrosing alopecia may be mediated by immune attacks at the bulge region, suggesting potential for JAK/STAT-targeting treatments to prevent progression.