Frontal Postmenopausal Alopecia

    January 2002 in “ Piel ”
    Roberta Olmo, J. Aneiros Cachaza, María Antonia Fernández Pugnaire, Agustín Buendía Eisman, S Serrano Ortega
    TLDR Postmenopausal women may experience frontal hairline and eyebrow loss due to cicatricial fibrosis.
    The study examined four postmenopausal women aged 55 to 75 with cicatricial frontal alopecia, characterized by a progressive regression of the hairline in the frontotemporal region, associated with cicatricial fibrosis. The analysis included clinical, analytical, and histological evaluations, revealing a predominance of CD8 positive T lymphocytes in the inflammatory infiltrate, with some B lymphocytes present in the dermis but not near the follicles. The findings suggested an absence of a lichenoid pattern, indicating that cicatricial fibrosis might represent an evolutionary step of the condition. All patients also experienced eyebrow alopecia, and one lost her eyelashes.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 3 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community Finasteride not working isnt it MPB?

      in Finasteride/Dutasteride  5 upvotes 1 year ago
      A user is concerned that finasteride isn't working for their hair loss, questioning if it's due to male pattern baldness or low iron levels. They are advised to take finasteride daily and get blood work done.

      community Quote from Pelage (PP-405) Spokesperson...

      in Research/Science  121 upvotes 2 months ago
      Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

      community Totally confused by doctors opinions, would appreciate some clarity

      in Treatment  1 upvotes 1 year ago
      The user is experiencing hair loss and confusion over conflicting medical advice, with treatments including minoxidil, finasteride, and topical corticosteroids. They are unsure about the necessity of a biopsy and the timing of using minoxidil, while also considering the impact of potential androgenetic alopecia and telogen effluvium.

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