40 citations
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January 2013 in “Frontiers in Endocrinology” Finger length ratios are not linked to the number of specific gene repeats affecting testosterone sensitivity.
9 citations
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July 2020 in “Journal of Dermatology” This study found that diffuse and pseudo-fringe sign patterns are common in Asian patients with frontal fibrosing alopecia, and that treatments combining antiandrogens or antimalarials with topical therapy are effective.
September 2023 in “Plant journal” This study showed that the zinc finger protein GIS3 is important for root hair growth in Arabidopsis by regulating RHD2 and RHD4 genes, with application of ethylene and cytokinin helping restore root hair presence in mutated variants.
3 citations
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September 2021 in “Journal of Clinical Medicine” In this study, fingertip regeneration in mice was associated with specific signaling pathways involving hair follicles and hedgehog signaling, with potential implications for improving human hand injury treatments.
3 citations
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February 2019 in “Disease Markers” This study reports that a lower 2D:4D finger length ratio is significantly associated with higher disease activity and reduced spinal mobility in females with ankylosing spondylitis, but not in males.
January 2025 in “Cell Communication and Signaling” This study reviews the role of the zinc finger protein CXXC5 in cellular signaling and its implications for cancer, discussing how its dysregulation is linked to various physiological and pathological processes, as well as potential therapies targeting CXXC5.
July 2024 in “Nursing Research” This study highlights the use of hair and fingernail cortisol levels as retrospective indicators of chronic stress, particularly in minoritized populations facing social stressors that increase the risk of mental health issues.
September 2023 in “UCrea (University of Cantabria)” In this study, researchers found that mouse digits without nails could not regenerate after amputation, highlighting the necessity of nails for fingertip regeneration and suggesting a potential role for the Lmx1b gene in this process.
February 2023 in “Indian journal of private psychiatry/Indian Journal of Private Psychiatry” This case report highlights a rare instance of fingernail and toenail hyperpigmentation following the use of valproic acid, which resolved after discontinuation of the drug.
8 citations
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September 2016 in “Journal of Investigative Dermatology” In this study, Flii overexpression in mice enhanced fingertip regeneration and nail formation after both distal and proximal amputations, suggesting a role in digit and hair follicle regeneration possibly involving Wnt signaling.
1 citations
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June 2019 in “Gut” This case report describes a 75-year-old carpenter with unexplained weight loss, fingernail loss, and discoloration of the palms and soles, whose diagnostic investigations revealed hypertrophic pangastritis and enteritis.
November 2025 in “Journal of Medicine and Health Technology” In this study, researchers found that none of the participants were color blind and reported varying lengths of index and ring fingers among them, exploring a possible link between these finger length ratios and sex-influenced gene expression.
June 2020 in “Zenodo (CERN European Organization for Nuclear Research)” This study found that all five toxic microelements analyzed were most prevalent in the Caspian thin-fingered gecko's bone and muscle tissues, suggesting their tolerance to these elements in polluted areas.
March 2020 in “UTUPub (University of Turku)” This study found that self-reported androgen-driven phenotypes, like balding and finger length ratios, were not associated with cancer aggressiveness or biochemical recurrence in prostate cancer after prostatectomy.
May 2015 in “Plastic and Reconstructive Surgery” This article introduces a novel, inexpensive hair preparation technique using glove-finger sheaths to secure and protect hair during calvarial surgery, reducing procedure time and hair damage without the need for full scalp shaving.
112 citations
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January 2004 in “The International journal of developmental biology” This study found that feather patterning is primarily self-organizing and dynamic, relying on both genetic and epigenetic controls, with implications for similar processes like fingerprints and pigmentation.
176 citations
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August 1981 in “JAMA” This study reported that toxic shock syndrome, originally noted in children, is now predominantly associated with menstruating women, with some experiencing recurrence and complications like vocal cord paralysis and impaired finger sensation.
26 citations
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October 2016 in “Case Reports in Dermatology” In this study, tofacitinib treatment in a male patient with alopecia areata led to significant hair regrowth and improvement in nail dystrophy symptoms, restoring finger function within 10 months.
2 citations
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June 2025 in “Drug Testing and Analysis” This study found that after application of a testosterone cream containing 17α-methyltestosterone and testosterone propionate, these compounds could be detected in dried blood spots up to 97 hours post-application, potentially leading to sample contamination during fingertip puncture.
1 citations
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January 2001 in “PubMed” This study proposes that the terminal tuft structure in sensory nerve endings, involving Schwann cell processes and axon fingers, potentially plays a role in mechano-electric transduction in rats.
May 2026 in “Signal Transduction and Targeted Therapy” This study found that rete ridge morphogenesis in mammalian skin is directed by a BMP-dependent developmental program, which is evolutionarily distinct from other known pathways controlling the development of hair follicles, sweat glands, and fingerprint ridges.
August 2023 in “Clinical, Cosmetic and Investigational Dermatology” In this article, researchers describe a novel FUE device designed to enhance follicular unit excision surgery by minimizing follicular injury and improving ergonomics with features such as Bluetooth functionality, fingertip touch sensors, and automated operation.
September 2018 in “Gynecology & Obstetrics” In a meta-analysis of 210 hair tourniquet syndrome cases, this study reported that 44.2% involved the penis, 40.4% the toes, and 8.6% fingers, highlighting the condition's potential severity and underreporting, especially in infants and some adults with cognitive impairments.
April 2017 in “Journal of Investigative Dermatology” This case study reports that a heterozygous missense GJA1 mutation, p.Gly138Ser, in a 2-year-old boy with oculodentodigital syndrome primarily resulted in syndactyly, fifth finger hypoplasia, and hypotrichosis, without neurological or craniofacial abnormalities.
July 2025 in “Clinical Case Reports” In this case report, a 17-year-old male with a specific TRPS1 gene mutation presented with sparse, soft hair, short thumbs and toes, misaligned teeth, and distinctive bone abnormalities in the fingers and toes as observed through X-ray analysis.
76 citations
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March 2008 in “Journal of the American Academy of Dermatology” This study found that videodermoscopy can help diagnose nailbed psoriasis by revealing distinctive hyponychial capillary patterns, which correlated with disease severity and response to treatment.
26 citations
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June 2018 in “The journal of immunology/The Journal of immunology” This study demonstrated that AIRE-deficient rats exhibit key symptoms of APECED, making them a relevant model for exploring potential treatments.
5 citations
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August 2023 in “Skin Research and Technology” In this study, fMRI results suggested that mechanical stimulation evoked a stronger prickle sensation comprising both pain and itch on hairy skin compared to glabrous skin.
5 citations
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January 2016 in “European Journal of Dermatology” Suplatast tosilate successfully treated a woman's systemic sclerosis symptoms.
This study found that structural changes in the stroma surrounding hair follicles and skin laxity are associated with the appearance of large pores, regardless of ethnicity or age.