20 citations
,
January 2005 in “Australasian Journal of Dermatology” This article describes a case of late-onset focal dermal elastosis in a 73-year-old woman, characterized by flat pale yellow lesions and increased normal elastic fibers, distinct from pseudoxanthoma elasticum.
10 citations
,
October 2018 in “Journal of molecular and cellular cardiology/Journal of Molecular and Cellular Cardiology” This study identified NM_026333 as a potential anti-aging gene that, when induced, may alleviate proton-induced aging symptoms in CF6-overexpressing and high salt-fed mice.
14 citations
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December 2020 in “Journal of Investigative Dermatology” This study observed that aging leads to significant structural and biological changes in the scalp's hair follicle environment in women, which may affect hair growth.
December 2021 in “Dermatology research” This study found that individuals with premature graying of hair had significantly lower serum levels of vitamin B12, ferritin, and calcium compared to those without premature graying.
20 citations
,
August 2014 in “PloS one” This study found that MED1 deficiency in keratinocytes accelerates skin wound healing in young mice but delays healing in older mice, suggesting differential roles in epidermal regeneration with age.
35 citations
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May 2011 in “Experimental Dermatology” This study found that hair follicles undergo significant molecular changes with age, notably a decline in keratins and keratin-associated proteins, which may contribute to age-related hair alterations.
January 2012 in “Else Kröner-Fresenius Symposia” This symposium reported that DNA damage accumulation in aging stem cells affects genome integrity, highlighting novel mechanisms like Bmi1's role in DNA repair and the involvement of BATF in lymphoid differentiation.
January 2026 in “Arhiv za farmaciju” This paper reviews the evidence connecting androgen deficiency to skin ageing in men, emphasizing that reduced testosterone exacerbates ageing signs like epidermal thinning and decreased elasticity and advocates for tailored skincare and aesthetics for this demographic.
December 2024 in “Asian Journal of Medical Sciences” This study observed that a majority of female patients with chronic telogen effluvium had low serum ferritin levels without signs of clinical anemia, suggesting a possible link between low iron stores and hair loss.
May 2015 in “Journal of the American Academy of Dermatology” Certain drugs and supplements may contribute to hair loss in the frontal hairline in older women.
8 citations
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September 1997 in “Postgraduate medicine” This article describes various acute and chronic vulvar disorders post-menopause and summarizes identification and treatment strategies, but reports no new clinical findings.
May 2026 in “Russian Journal of Skin and Venereal Diseases” In this study, researchers observed a high prevalence of ferritin and vitamin D deficiency in women with acute telogen effluvium, highlighting the importance of laboratory screening for these deficiencies, while also noting a correlation between ferritin levels and hair loss severity.
May 2025 in “The Journal of Rheumatology” This study reports that even minimal improvements in SLE-related fatigue and skin symptoms are meaningful to patients, supporting the content validity of the FACIT-Fatigue scale for measuring these effects.
8 citations
,
January 2013 in “BioMed Research International” This study observed that both Factor XIIIa+ dermal dendrocytes and microvasculature size decreased with scalp aging and that alopecia changes resembled stress-induced premature senescence.
4 citations
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January 2014 in “The Journal of urology/The journal of urology” This study found that folliculin deficient renal cancer cells were more sensitive to irradiation due to increased autophagic cell death, suggesting a potentially enhanced therapeutic approach when combined with autophagy inducers like rapamycin.
76 citations
,
December 2006 in “Journal of Dermatological Science” This study observed that Japanese women experience diffuse central hair loss after age 40, characterized by reduced hair density and thicker hair ratio rather than vellus-like hairs.
August 2024 in “IAHS Medical Journal” This study, conducted among 50 women with female-pattern hair loss, observed that 89% had deficient or insufficient vitamin D levels and also showed low ferritin levels, suggesting these deficiencies may contribute to hair loss.
21 citations
,
July 2001 in “Clinics in dermatology” This review discusses the clinical use of nutraceuticals for skin aging in dermatological practices and reports no new clinical results.
4 citations
,
November 1999 in “PubMed” This article presents five family cases of monilethrix and reports that neither vitamins nor desquamative ointments are effective treatments, although symptoms may spontaneously regress over time.
January 2019 in “Elsevier eBooks” Skin aging helps us understand overall aging.
26 citations
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January 1983 in “PubMed” This study reports that despite normal cystine incorporation into hair follicles, trichothiodystrophy patients have decreased cystine levels in hair shafts, contradicting the hypothesis of defective transport in hair follicles.
3 citations
,
January 2011 in “Clinics in Dermatology” This article reviews the dermatological challenges and cultural influences affecting India's aging population, noting that while pigmentary disorders and cosmetic dermatology are prevalent, cutaneous cancers remain rare and often go undetected.
March 2026 in “Ageing Research Reviews” This review highlights the complex interplay between intrinsic and extrinsic factors influencing skin aging, emphasizing the need for advanced human-specific models to study aging mechanisms and develop new therapies.
15 citations
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March 1996 in “PubMed” This study found that 82.3% of girls with anorexia nervosa had pili torti, an acquired hair defect, suggesting a potential link to excess vitamin A intake.
May 2025 in “Skin Appendage Disorders” In this case study, a 74-year-old patient with frontal fibrosing alopecia displayed unique trichoscopic and histopathological features, and treatments like 5-alpha reductase inhibitors and oral minoxidil effectively halted disease progression, highlighting the importance of comprehensive facial analysis for prognosis.
7 citations
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October 2019 in “Elsevier eBooks” This chapter defines skin integrity as a blend of intact structural elements and adaptable functional capacity, highlighting its importance in maintaining skin health across various conditions but reports no new research findings.
23 citations
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October 2021 in “Cell Stem Cell” This study found that hair shaft miniaturization in aging and genetic hypotrichosis leads to hair follicle stem cell loss through mechanical compression and apoptosis mediated by the Piezo1 channel.
April 2026 in “Indian Dermatology Online Journal” This study found that individuals with premature graying of hair in India had significantly lower levels of serum ferritin, vitamin B12, and vitamin D3 compared to controls.
5 citations
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July 2022 in “Journal of Investigative Dermatology” Aged skin heals slower due to more inflammation and disrupted cell communication.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that age-related changes in scalp dermal fibroblasts, including increased MMP-1 and reduced ECM components, may significantly affect the hair follicle environment and contribute to hair aging.