20 citations
,
April 2011 in “British Journal of Dermatology” Reflectance confocal microscopy can tell apart white dots on the scalp as either sweat gland ducts or hair follicle openings.
211 citations
,
February 2009 in “European journal of pharmaceutics and biopharmaceutics” This review summarizes recent advancements in follicular targeting for drug delivery via hair follicles and calls for pilot studies in humans to explore potential clinical applications.
16 citations
,
July 2018 in “Experimental Dermatology” This study suggests that the transcription factor Gata6 plays a role in maintaining the structure of the upper hair follicle and may be implicated in conditions marked by its abnormal expansion, such as acne or cystic diseases.
April 2023 in “Rossijskij žurnal kožnyh i veneričeskih boleznej” This collection presents a photogallery on the follicular occlusion syndrome, uniting diseases like hidradenitis suppurativa under shared pathogenesis, but reports no new clinical results.
19 citations
,
January 2015 in “International Journal of Cosmetic Science” This study reports that optimized PLA nanoparticles can effectively target hair follicles to deliver both lipophilic and hydrophilic compounds, suggesting potential applications in hair cosmetics and treatments.
18 citations
,
October 2016 in “European Journal of Pharmaceutics and Biopharmaceutics” In this study, FITC-labeled BSA nanocarriers delivered a model drug deeper into porcine ear skin hair follicles than the carriers themselves, as shown by confocal microscopy.
103 citations
,
September 2004 in “Clinics in dermatology” This article discusses methods to measure comedogenesis in acne through the presence of microcomedones and reports no new clinical results; the authors outline a skin surface biopsy technique using cyanoacrylate gel.
48 citations
,
March 1997 in “Veterinary Dermatology” This report describes a paraneoplastic alopecia in four cats associated with internal malignancy, confirming previous findings of a syndrome linking ventral alopecia and metastatic carcinomas.
15 citations
,
May 2013 in “American Journal of Medical Genetics - Part A” People with X-linked hypohidrotic ectodermal dysplasia have no sweat ducts and less, thinner hair.
July 2026 in “Anais Brasileiros de Dermatologia” This study reported that both AGA and SD in Caucasian male patients showed overlapping histopathological features with FAPD, particularly perifollicular fibrosis and inflammation, complicating diagnosis.
37 citations
,
June 2011 in “Journal of The American Academy of Dermatology” This study demonstrates that sebaceous gland loss is a common early feature in primary scarring alopecia and suggests that inflammation of sebaceous glands or ducts may contribute to follicular damage.
1 citations
,
September 2016 in “Springer eBooks” This article reports no new data; it describes the role of sebum in influencing the skin microbiome and epithelial tissues and discusses its altered composition during transit through the sebaceous duct.
April 2018 in “Journal of Investigative Dermatology” Mutations in Far2 mice cause hair loss due to sebaceous gland issues.
This abstract discusses the classification of scarring alopecia, distinguishing it from secondary scarring alopecia and detailing its subtypes based on inflammation patterns and cells present during the disease's active phase, but reports no new clinical results.
32 citations
,
September 2018 in “Journal of pharmaceutical sciences” This study extended a skin diffusion model to include a porous pathway, effectively explaining the permeability of both polar and lipophilic solutes through the stratum corneum.
December 2025 in “Skin Appendage Disorders” This review explores the under-researched role of apocrine glands in the human scalp, suggesting they may play a significant part in waste removal, electrolyte balance, interaction with the microbiome, and the pathogenesis of follicular occlusion diseases, despite being often overlooked.
January 2025 in “Indian Journal of Dermatopathology and Diagnostic Dermatology” In this histopathology study of nevus sebaceus, researchers observed distinct epidermal, sebaceous, follicular, and apocrine changes, including sebaceous hyperplasia and basaloid adnexal proliferation, which help differentiate it from similar conditions like basal cell carcinoma and trichoblastoma.
56 citations
,
October 2010 in “Pediatric Clinics of North America” This article discusses various types of epidermal nevi and associated syndromes but presents no new research findings.
5 citations
,
January 2017 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” This review reports two new cases of porokeratotic eccrine and hair follicle nevus and analyzes all known cases in the Spanish and English literature, suggesting a link to a GJB2 gene mutation.
June 2025 in “Australasian Journal of Dermatology” This study introduced and evaluated a new dermoscopic feature, pigmented rings with central clearing, for improving the diagnosis of melasma and differentiating it from similar conditions.
1 citations
,
November 2009 in “Cambridge University Press eBooks” This article reports that follicular unit extraction is a minimally invasive hair restoration technique that avoids linear scarring and reduces donor-site pain compared to traditional strip harvesting methods.
109 citations
,
November 2005 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This article discusses the role of hair follicles in enhancing topical drug delivery and explores strategies for targeting these areas to improve treatment outcomes for skin diseases, but reports no new research results.
12 citations
,
February 1997 in “British Journal of Dermatology” This study found that 5α–reductase activity is higher in infrainfundibular keratinocytes compared to interfollicular epidermal keratinocytes, suggesting a potential role in acne-related follicular changes.
2 citations
,
June 2001 in “American Journal of Pathology” This article explores the complexity and significance of the hair follicle, emphasizing new insights into its biological roles and the involvement of p53 in follicular regression.
1 citations
,
April 2016 in “Actas Dermo-Sifiliográficas” Wearing a wig caused a woman's skin condition to worsen due to pressure from the wig's fasteners.
316 citations
,
June 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that using a standardized protocol with microspheres of approximately 1.5 micrometers enhances penetration into hair follicles, particularly when skin is treated with cyanoacrylate skin surface stripping.
89 citations
,
November 2014 in “International Journal of Nanomedicine” This study suggests that spironolactone-loaded nanostructured lipid carriers could enhance follicular delivery and offer a more localized treatment for androgenic alopecia, potentially reducing systemic side effects.
35 citations
,
October 2015 in “International Journal of Pharmaceutics” Tiny particles carrying roxithromycin can effectively target and deliver the drug to hair follicles without irritation.
31 citations
,
September 2014 in “Journal of Pharmaceutical Sciences” This study found that Er–YAG laser treatment significantly enhanced skin absorption and follicular delivery of antialopecia drugs, suggesting a potential laser-assisted approach to treat alopecia.
26 citations
,
March 2014 in “International journal of pharmaceutics” This study confirmed that the novel solid lipid microparticle formulation of adapalene demonstrated follicular penetration potential and targeted particle erosion in sebum in in vitro tests.