Follicular Unit Extraction: Advances and Challenges

    November 2009 in “ Cambridge University Press eBooks ”
    James A. Harris
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    TLDR FUE is a less invasive hair restoration method with potential to become standard, offering benefits like reduced scarring and pain, but requires experience to minimize risks.
    In 2009, Follicular Unit Extraction (FUE) was described as a hair restoration technique that individually removes follicular units, offering advantages like less invasiveness, reduced pain, and no linear scarring. Challenges included a high transection risk and a steep learning curve, with initial transection rates at 5.6%, which could be reduced to less than 2% with experience. The SAFE System, using a dull punch, was developed to lower transection rates, with reported rates between 1.3% and 4% depending on the punch size. FUE was also less tissue-removing compared to traditional strip harvesting and allowed patients to wear hair short. The document noted the potential for FUE to become the standard for graft production due to improvements in techniques and instruments, predicting decreased operating times and costs, and the advent of mechanized and robotic technologies. However, the document also acknowledged the scarcity of published reports on FUE and based its information on anecdotal evidence.
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      in Treatments 5 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community How is verteporfin doing in trials?

      in Chat  9 upvotes 11 months ago
      The conversation is about the progress of verteporfin in hair loss trials, with users expressing curiosity about its effectiveness and updates. Specific treatments mentioned include FUE (Follicular Unit Extraction) combined with verteporfin, with one reported case of donor area regrowth after a year, and three patients being monitored post-treatment by Dr. Bloxham with monthly updates on YouTube.

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