research Antioxidants and Lipid Peroxidation Status in the Blood of Patients with Alopecia
Alopecia patients have lower antioxidants and higher lipid damage in their blood.
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570-600 / 1000+ resultsresearch Conversion of C57Bl/6 Mice from a Tumor Promotion-Resistant to a Sensitive Phenotype by Enhanced Ornithine Decarboxylase Expression
The study developed a transgenic mouse model to investigate the role of ornithine decarboxylase (ODC) in tumor promotion. By overexpressing ODC in hair follicle keratinocytes of C57Bl/6 mice using a tetracycline-regulated system, researchers found that high levels of ODC activity led to significant epidermal hyperplasia and increased sensitivity to tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA). This effect was reversible with doxycycline, which repressed transgene expression. The findings indicated that enhanced ODC expression converted the typically tumor-resistant C57Bl/6 mice to a tumor-sensitive phenotype, highlighting the potential role of ODC in tumor promotion.
research 5α-Reductase Inhibitors/Finasteride: A Safe and Effective Treatment for Benign Prostatic Hyperplasia
Finasteride is a safe and effective long-term treatment for prostate enlargement, reducing prostate volume and related symptoms.
research Role of Prolactin in Regulating the Onset of Winter Fur Growth in Mink: A Reconsideration
Prolactin levels do not control the start of winter fur growth in mink.
research Conversion of C57Bl/6 Mice from a Tumor Promotion-Resistant to a Sensitive Phenotype by Enhanced Ornithine Decarboxylase Expression
The study developed a transgenic mouse model to investigate the role of ornithine decarboxylase (ODC) in tumor promotion. By using a tetracycline-regulated system, researchers were able to overexpress ODC specifically in hair follicle keratinocytes of C57Bl/6 mice. In the absence of doxycycline, these mice showed high levels of epidermal ODC activity and hyperplasia when exposed to the tumor promoter TPA, particularly affecting hair follicles. This effect was reversed by adding doxycycline, which repressed transgene expression. The study concluded that increased ODC expression made the typically tumor-resistant C57Bl/6 mice more susceptible to tumor promotion by TPA, highlighting the significance of ODC in tumor development.
research Enhanced Delivery of Drugs Into and Across the Skin by Ethosomal Carriers
Ethosomal carriers improve drug delivery through the skin better than traditional methods.
research Prodrugs of Butyric Acid from Bench to Bedside: Synthetic Design, Mechanisms of Action, and Clinical Applications
New butyric acid prodrugs show promise for cancer treatment, anemia management, and protecting hair from chemotherapy damage.
research Effects of Finasteride, a Type 2 5-Alpha Reductase Inhibitor, on Fetal Development in the Rhesus Monkey (Macaca Mulatta)
Finasteride, when given in high oral doses to pregnant monkeys, caused genital abnormalities in male fetuses, but not in female fetuses or those exposed to intravenous finasteride.
research Molecular Histology in Skin Appendage Morphogenesis
New molecules involved in skin and hair growth were identified, improving understanding and future treatments.
research Effect of Finasteride and/or Terazosin on Serum PSA: Results of VA Cooperative Study #359
Finasteride reduces PSA levels, terazosin doesn't affect them, and tracking prostate cancer in patients taking finasteride could be difficult.
research Regulation of Human Dermal Papilla Cell Production of Insulin-Like Growth Factor Binding Protein-3 by Retinoic Acid, Glucocorticoids, and Insulin-Like Growth Factor-1
Retinoic acid, glucocorticoids, and IGF1 increase IGFBP-3 production in human dermal papilla cells, affecting hair growth.
research Crosslinking Structure of Keratin: Number and Type of Crosslinks in Microstructures of Untreated and Potassium Cyanide Treated Human Hair
Potassium cyanide treatment changes hair's disulfide bonds, making it more elastic.
research Synthesis and Biological Evaluation of 4-(4-(Alkyl- and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-Steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2
The compound 4c effectively inhibits the enzyme linked to hair loss.
research Effect of Finasteride and/or Terazosin on Serum PSA: Results of VA Cooperative Study #359
Finasteride reduces PSA levels, terazosin doesn't affect them, and tracking prostate cancer in patients taking finasteride could be difficult.
research The Evolution of Primary Multimodality Treatment in Resectable Breast Cancer
Multimodal primary treatment improves survival in premenopausal breast cancer patients and is also beneficial for postmenopausal women.
research Expression and Function of FGFs-4, -8, and -9 Suggest Functional Redundancy and Repetitive Use as Epithelial Signals During Tooth Morphogenesis
FGFs-4, -8, and -9 have overlapping roles and are repeatedly used in tooth development.
research Neurotrophins, Nociceptors, And Pain
Neurotrophins, especially NGF, are crucial for pain development and management.
research Ability to Culture Dermal Papilla Cells from Red Deer Hair Follicles with Differing Hormonal Responses In Vivo Offers a New Model for Studying the Control of Hair Follicle Biology
Red deer hair cells offer a new way to study how hormones affect hair growth.
research Protection Against Cyclophosphamide-Induced Alopecia and Inhibition of Mammary Tumor Growth by Topical 1,25-Dihydroxyvitamin D3 in Mice
Rubbing vitamin D3 on skin can help prevent hair loss from chemotherapy and slow breast tumor growth in mice.
research Sperm Aneuploidy in Infertile Male Patients: A Systematic Review of the Literature
Infertile men are more likely to produce sperm with abnormal chromosome numbers, which can affect pregnancy success and embryo health.
research Clinical Features of Primary Cicatricial Alopecia in Chinese Patients
Chinese patients with primary cicatricial alopecia often have folliculitis decalvans, benefit from treatment, but may experience relapse, with dermoscopy being a useful diagnostic tool.
research Minoxidil Improves Vascular Compliance, Restores Cerebral Blood Flow, and Alters Extracellular Matrix Gene Expression in a Model of Chronic Vascular Stiffness
Minoxidil improves blood flow and vessel flexibility, potentially helping with vascular stiffness.
research Aggressive Squamous Cell Carcinoma Developing in a Giant Epidermal Cyst of the Abdomen
A woman died from cancer that spread from a long-standing cyst on her abdomen.
research Laser Hair Transplantation
Laser hair transplantation can be effective but should be limited to small areas and requires more training to ensure safety and effectiveness.
research The Therapeutic Promise of Apoptosis
Blocking cell death in certain stem cells can improve wound healing and tissue regeneration.
research The Murine Hair Follicle Is a Melatonin Target
Melatonin directly affects mouse hair follicles and may influence hair growth.
research Pharma in the Bedroom and the Kitchen: The Pharmaceuticalisation of Daily Life
The conclusion is that the increasing use of drugs for lifestyle reasons is a complex issue influenced by corporate profit, consumer behavior, and the medicalization of everyday life, with potential negative effects on personal well-being.
research Frontal Fibrosing Alopecia: An Update on Pathogenesis, Diagnosis, and Treatment
The cause of Frontal Fibrosing Alopecia is unclear, diagnosis involves clinical evaluation and various treatments exist, but their effectiveness is uncertain.
research 25 Years of Epidermal Stem Cell Research
Research on epidermal stem cells has advanced significantly, showing promise for improved clinical therapies.
research SALT II: A New Take on the Severity of Alopecia Tool for Determining Percentage Scalp Hair Loss
The updated SALT II tool offers a more precise way to measure scalp hair loss.