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    Glossary Scarless Wound Healing

    process where tissue repairs without forming a scar

    Scarless wound healing refers to the process by which the body repairs tissue damage without forming a scar. This type of healing is typically seen in fetal development and involves a complex interplay of cellular and molecular mechanisms that promote tissue regeneration rather than fibrosis. For professionals, it is of particular interest because understanding these mechanisms could lead to advanced treatments for improving wound healing in adults.

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    1. Scarless wound healing: Transitioning from fetal research to regenerative healing Wiley Interdisciplinary Reviews-Developmental Biology · 2018 · 79 citations
    2. Fetuin-A: A Major Fetal Serum Protein that Promotes “Wound Closure” and Scarless Healing Journal of Investigative Dermatology · 2007 · 21 citations
    3. Scarless wound healing – a literature review Romanian Journal of Pediatrics · 2019 · 2 citations
    4. Chapter 6 Fetal Skin Wound Healing Advances in Clinical Chemistry · 2009 · 89 citations
    5. Role of boundary conditions in an experimental model of epithelial wound healing The Year book of surgery · 2007
    6. Confocal Microscopic Analysis of Scarless Repair in the Fetal Rat Plastic & Reconstructive Surgery · 2002 · 99 citations
    7. Wound healing 2012
    8. Regeneration, Wound Healing and Cancer 2017 · 1 citations
    9. Hydrogen peroxide disrupts scarless fetal wound repair Wound Repair and Regeneration · 2005 · 41 citations
    10. An In Vivo Mouse Excisional Wound Model of Scarless Healing Plastic and Reconstructive Surgery · 2006 · 58 citations
    11. Impact of different mating and surgical protocols on the establishment of a mouse model for fetal scarless skin healing Biological Procedures Online · 2025
    12. Fibroblast Lineage Switching as the Developmental Origin of Scarring and Target for Regenerating Healing Preprints.org · 2026
    13. Animal models for the study of fetal tissue repair Journal of Surgical Research · 1991 · 69 citations
    14. Ontogenetic Transition in Fetal Wound Transforming Growth Factor-β Regulation Correlates with Collagen Organization American Journal of Pathology · 2003 · 109 citations
    15. A Scarless Healing Tale: Comparing Homeostasis and Wound Healing of Oral Mucosa With Skin and Oesophagus Frontiers in Cell and Developmental Biology · 2021 · 42 citations
    16. New potential antiscarring approaches Wound Repair and Regeneration · 2011 · 10 citations
    17. The developing immune network in human prenatal skin Immunology · 2020 · 11 citations
    18. Differential Expression of Fibromodulin, a Transforming Growth Factor-β Modulator, in Fetal Skin Development and Scarless Repair American Journal of Pathology · 2000 · 168 citations
    19. Modulating embryonic signaling pathways paves the way for regeneration in wound healing Frontiers in physiology · 2024
    20. Wound Healing: A Paradigm for Regeneration Mayo Clinic Proceedings · 2013 · 64 citations
    21. Fibromodulin reduces scar formation in adult cutaneous wounds by eliciting a fetal-like phenotype Signal Transduction and Targeted Therapy · 2017 · 35 citations
    22. Minimizing Skin Scarring through Biomaterial Design Journal of Functional Biomaterials · 2017 · 23 citations
    23. Twist2 contributes to skin regeneration and hair follicle formation in mouse fetuses Scientific reports · 2024
    24. Twist2 contributes to skin regeneration and hair follicle formation in mouse fetuses Research Square (Research Square) · 2024
    25. Procesul de vindecare fără cicatrizare – review de literatură Romanian Journal of Pediatrics · 2019
    26. Skin biology Elsevier eBooks · 2019 · 5 citations
    27. Wound healing in development Birth Defects Research · 2012 · 29 citations
    28. Mammalian Fetal Organ Regeneration 2005 · 32 citations
    29. Fetal wound healing using a genetically modified murine model: the contribution of P-selectin Journal of Pediatric Surgery · 2008 · 10 citations
    30. Pro‐Regenerative Hydrogel Restores Scarless Skin during Cutaneous Wound Healing Advanced Healthcare Materials · 2017 · 41 citations