128 citations,
December 2006 in “Journal of Biological Chemistry” The study explored how altering the expression of spermidine/spermine N1-acetyltransferase (SSAT) affected fat metabolism in mice. Transgenic mice overexpressing SSAT showed increased metabolic activity through the polyamine pathway, resulting in a leaner phenotype with reduced white adipose acetyl- and malonyl-CoA pools and enhanced glucose and palmitate oxidation. In contrast, SSAT knockout mice had decreased metabolic flux, increased body fat, and lower oxidation rates, especially on a high-fat diet. These results indicated that SSAT expression influenced acetyl- and malonyl-CoA levels, affecting fatty acid biosynthesis and oxidation, and thus body fat accumulation. The study underscored the role of SSAT in polyamine metabolism and its impact on fat metabolism via acetyl-CoA modulation.
38 citations,
January 2002 in “Biological & Pharmaceutical Bulletin” Lygodii Spora extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.
31 citations,
April 2018 in “Royal Society open science” Sarcoptes scabiei infection causes significant health and behavior changes in wombats.
29 citations,
July 1996 in “Acta Paediatrica” Biotin should be added to Japanese amino acid formula to prevent deficiency.
15 citations,
January 2016 in “Dermatologic Clinics” Start acne treatment early to prevent scarring, consider antibiotic resistance, use maintenance therapy, and manage side effects carefully.
15 citations,
May 2010 in “International Journal of Cosmetic Science” The cell membrane complex in mammalian hair has three distinct types with different structures and chemical properties.
13 citations,
July 1978 in “Journal of comparative pathology” Acanthospermum hispidum is toxic to mice, causing death and damage to internal organs.
11 citations,
December 2022 in “Arterial Hypertension” New guidelines stress early diagnosis and lifestyle changes to manage metabolic syndrome and prevent complications.
11 citations,
January 2020 in “Medical Journal Armed Forces India” Insulin resistance is a complex condition that can lead to many diseases and has few treatment options.
10 citations,
October 2010 in “Hepatology” Certain liver diseases respond well to specific treatments and have varying risks for liver cancer.
7 citations,
September 2023 in “Cancer Treatment Reviews” Managing side effects of endocrine therapy is crucial to improve adherence and survival in breast cancer patients.
7 citations,
January 2007 in “Elsevier eBooks” Shampoos clean hair mainly with surfactants and have added ingredients for extra benefits.
6 citations,
August 2022 in “International Journal of Molecular Sciences” EDA signaling is linked to skin disorders, various cancers, and liver disease.
5 citations,
August 2018 in “Thai Journal of Pharmaceutical Sciences (TJPS)” Riceberry by-products may promote hair growth and skin pigmentation, useful for cosmetics.
4 citations,
December 2009 in “Elsevier eBooks” Breadfruit is nutritious and has potential health and medicinal benefits, but is currently underused.
4 citations,
September 2003 in “PubMed” Low protein diets cause severe health issues in rats, but high protein diets can reverse these effects.
3 citations,
January 2023 in “Physiological Research” Conditioned media from mesenchymal stem cells show promise for tissue repair and disease treatment, but more research is needed on their safety and effectiveness.
1 citations,
October 2022 in “Journal of food and nutrition research” Cinnamon may help manage obesity and improve conditions related to Polycystic Ovary Syndrome (PCOS).
1 citations,
October 2022 in “The American Journal of Gastroenterology” This document presents a case of a 29-year-old woman with chronic arsenic exposure leading to hepatic steatosis and acute liver injury. The patient exhibited symptoms such as abdominal pain, nausea, vomiting, and a range of neurological and systemic issues, including polyneuropathy and encephalopathy. Despite initial negative tests for heavy metals, elevated arsenic levels were found in hair and nail samples. The case highlights the association between arsenic toxicity and liver conditions like non-cirrhotic portal fibrosis and non-alcoholic fatty liver disease, emphasizing the importance of recognizing metal toxicity in liver injury diagnosis and management.
A high fat lard diet may protect against skin fibrosis and affect hair growth.
March 2024 in “Journal of Endocrinological Investigation” Finasteride treatment in rats changed the expression of genes related to psychiatric and neurological functions, and these changes persisted after stopping the drug.
October 2023 in “Cognizance journal” The document suggests using natural remedies like bloodletting and honey for various health issues but lacks scientific evidence for their effectiveness.
June 2022 in “Farmacevtičnij časopis” The conclusion is that the technology for making "Biosedum plus" gel, which treats radiation skin damage, is validated.
January 2022 in “Figshare” Autophagy helps mouse glands stay healthy, prevents early aging, and maintains their oil and scent production.
July 2021 in “Journal of dermatology research and therapy” Using combined treatments can help manage acne by targeting the bacteria and skin changes that cause it.
Pumpkin roots contain compounds like Alpha-spinasterol, squalene, and palmitic acid, which may have health benefits like reducing depression, treating certain cancers, and having antibacterial properties.
January 2021 in “Figshare” Autophagy helps delay aging in mouse glands, maintains fat balance, and controls scent production.
Injecting patients' own PRP into their thyroid improved thyroid function and symptoms in most hypothyroidism cases.
January 2019 in “Springer Reference Medizin” Follicle Stimulating Hormone is important for fertility.
January 2018 in “Computational Toxicology” Pharmacophore models can predict liver toxicity and central nervous system toxicity, but they have limitations and specific requirements.