TLDR Acanthospermum hispidum is toxic to mice, causing death and damage to internal organs.
The study investigated the toxicity of Acanthospermum hispidum in 50 albino mice, which were fed varying concentrations (1-50%) of the plant's shoots and seeds. All dose levels proved toxic, causing death within 9 to 172 days. Symptoms of poisoning included diarrhea, dyspnea, alopecia, and general deterioration. Autopsies revealed significant organ damage, including fatty changes and necrosis in the liver, renal glomerular shrinkage, and hemorrhage and congestion in the spleen, lungs, and heart, along with catarrhal enteritis.
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June 2010 in “Nature” Alopecia areata involves both innate and adaptive immunity, with specific genes linked to the disease.
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August 2014 in “Nature medicine” Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.
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October 1998 in “Endocrinology” Diet can prevent bone issues but not hair loss in mice lacking vitamin D receptors.
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April 2012 in “The New England Journal of Medicine” Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.
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January 2010 in “Journal of The American Academy of Dermatology” Half of people with Alopecia Areata may see hair regrowth within a year without treatment, but recovery is unpredictable.
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January 2006 in “Journal of the American Academy of Dermatology” Alopecia areata, a common autoimmune hair loss condition, often runs in families.
