August 2021 in “Annals of Agricultural and Environmental Medicine” This review provides a detailed analysis of frontal fibrosing alopecia, focusing on its prevalence in postmenopausal Caucasian women, associated comorbidities, and potential autoimmune, genetic, hormonal, and environmental factors; it emphasizes the need for improved understanding to enhance diagnosis and treatment.
155 citations
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September 2008 in “British journal of dermatology/British journal of dermatology, Supplement” This study observed that frontal fibrosing alopecia predominantly affects postmenopausal women, can be associated with lichen planus, and may lead to progressive hairline recession, though this progression is not consistent in all cases.
March 2026 in “International Journal of Science and Research (IJSR)” This research focused on Eclipta prostrata, revealing unique anatomical features and bioactive compounds such as alkaloids and flavonoids that can aid in reliable identification and quality control of this medicinal herb, commonly used for hair growth and liver health.
This study reported that prompt diagnosis and treatment with 5-alpha-reductase inhibitors and topical immunomodulators are key to mitigating the effects of frontal fibrosing alopecia and preventing permanent hair loss.
June 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study evaluated a polyherbal Ayurvedic hair regrowth oil containing various plant extracts and found that the F2 formulation significantly enhanced hair growth in albino rats, suggesting potential for promoting hair growth and scalp health in humans, though further clinical testing is needed.
4 citations
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April 2019 in “DOAJ (DOAJ: Directory of Open Access Journals)” This review highlights available treatments for frontal fibrosing alopecia, noting that 5-alpha reductase inhibitors, intralesional steroids, and hydroxychloroquine currently have the most evidence supporting their use, while other treatments show variable results and require further study.
April 2026 in “Journal of Natural Remedies” This review presents a comprehensive evaluation of eleven traditional herbs, detailing their phytochemical properties, mechanisms, pharmacokinetics, and potential roles in managing alopecia, positioning them as holistic alternatives to conventional treatments like minoxidil and finasteride.
9 citations
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August 2018 in “Journal der Deutschen Dermatologischen Gesellschaft” This study provides the most comprehensive review to date of published cases of frontal fibrosing alopecia, emphasizing a notable association with thyroid disease.
59 citations
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January 2003 in “Phytomedicine” This study found that a cream containing 2% Fennel extract reduced hair diameter in idiopathic hirsutism patients more effectively than a cream with 1% Fennel or a placebo.
March 2026 in “PubMed Central” This study reports that the prevalence of female pattern hair loss increases with age, affecting 12% of women by age 29, 25% by age 50, and 41% to 50% by age 70 and older, with risk factors including genetics and certain endocrinological conditions.
December 2023 in “Plants” The researchers investigated the phytochemical content and pharmacological properties of Fissistigma oldhamii and found multiple compounds, primarily in roots and stems, that may contribute to the plant's traditional anti-inflammatory uses in China, including potential antioxidant, anticancer, and antimicrobial effects.
Female pattern hair loss, common in women, can be treated with various methods like minoxidil, anti-androgen treatments, and light therapy, but early intervention and realistic expectations are crucial.
1 citations
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January 2019 This article discusses various treatments for alopecia, including allopathic, homeopathic, and Ayurvedic methods, as well as the traditional use of certain herbs, but reports no new clinical results.
12 citations
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January 2020 in “Indian Dermatology Online Journal” This article discusses the causes, diagnosis, and treatment options for female pattern hair loss, emphasizing the role of topical minoxidil as a primary treatment, but provides no new clinical results.
December 2022 in “Research Square (Research Square)” This study found that an extract from the herbal medicine Ophioglossum vulgatum Linn. showed potential hair growth promotion and increased ATP and catalase activity in cell assays, suggesting its use in treating alopecia.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This study found that the methanol leaf extract of Ficus platyphylla demonstrated a high margin of acute safety in Wistar rats, showing minimal risk under short-term exposure with no mortality at doses up to 5000 mg/kg and no significant changes in liver enzyme activities.
January 2022 in “Дерматологія та венерологія” This paper presents two cases of frontal fibrosing alopecia in postmenopausal women, noting challenges in monitoring due to the invasive nature of the diagnostic process.
2 citations
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January 2010 in “PubMed” This case report observed no hair regrowth after treating a woman with postmenopausal frontal fibrosing alopecia using systemic and local corticosteroids, suggesting the need for more innovative therapies.
1 citations
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January 2018 in “Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.)” This study found that a herbal shampoo and solution were more effective than placebo in reducing hair loss and improving hair growth in participants with androgenetic alopecia and telogen effluvium.
September 2023 in “Zenodo (CERN European Organization for Nuclear Research)” This source compiles information on Calotropis gigantea, an Asclepiadaceae plant used in traditional medicine for treating conditions like leprosy, asthma, vertigo, and hair loss, highlighting its diverse medicinal potential.
42 citations
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July 2015 in “Drug Development and Industrial Pharmacy” This study concluded that Flutamide-loaded solid lipid nanoparticles may enhance hair follicle drug delivery and promote hair growth in androgenic alopecia compared to a Flutamide hydroalcoholic solution.
April 2022 in “Actas Dermo-Sifiliográficas” This article discusses the case of a 59-year-old woman with a history of progressive facial hyperpigmentation and explores potential connections between her condition and her family history, but reports no clinical findings.
March 2023 in “International Journal of Advanced Research in Science, Communication and Technology” This article discusses various synthetic and herbal treatments for alopecia, noting limited effectiveness and associated side effects of synthetic options, and reports no new clinical results.
75 citations
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December 2011 in “British Journal of Dermatology” This review discusses female pattern hair loss, its psychological impact, and available treatments but provides no new clinical findings; the authors emphasize early intervention for better outcomes.
2 citations
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November 2009 in “DSpace (Federal University of Santa Catarina)” Brunfelsia uniflora has good antioxidant properties and moderate antibacterial activity.
This study reports that a polyherbal hair mask made from ingredients like strawberry, amla, and fenugreek demonstrates effectiveness as a non-toxic alternative to chemical hair products, promoting hair growth and scalp nourishment while offering ease of use and stability.
14 citations
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January 2015 in “Current problems in dermatology” This review addresses treatment approaches for female pattern hair loss, highlighting that combining different therapies may be more effective than single treatments, but no new results are reported.
April 2023 in “JAAD international” This study observed that among a Moroccan population with frontal fibrosing alopecia, common comorbidities included lichen planus pigmentosus (36.8%), rosacea (28.9%), thyroid disorders (23.7%), and dyslipidemia (21.1%), highlighting potential relationships mediated by shared inflammatory or metabolic pathways.
7 citations
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May 2013 in “PubMed” In this randomized, placebo-controlled study, the tested cosmetic ingredient containing Trifolium pratense flower extract and a biomimetic peptide increased anagen hair and improved the anagen/telogen ratio over four months in individuals with recessing hair.