Steven Kossard's Postmenopausal Frontal Fibrosing Alopecia: A Therapeutic Dilemma

    January 2010 in “ PubMed ”
    Georgi Tchernev, Michael Tronnier
    TLDR Current treatments for postmenopausal frontal fibrosing alopecia stop hair loss but don't regrow hair.
    Steven Kossard identified a type of hair loss called postmenopausal frontal fibrosing alopecia (PFFA), characterized by symmetric regression of the frontal hairline and often affecting the eyebrows, primarily in elderly women. Histological analysis showed lichen planopilaris, but no other signs of lichen planus were observed in the body. Treatment with systemic and local corticosteroids halted disease progression, but no hair regrowth was noted over a 6-month period. Although a hormonal basis was not confirmed, the effectiveness of finasteride in some cases suggested a potential androgenic role in the disease's pathogenesis. Corticosteroids did not achieve permanent remission or hair regrowth, indicating a need for more advanced treatments, such as skin transplantation and 5-alpha reductase inhibitors, which have shown efficacy in male androgenetic alopecia.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Diffuse thinning is so brutal.

      in Styling  73 upvotes 2 years ago
      A 25-year-old with AGA experienced hair thinning and dandruff, stabilized with topical finasteride and minoxidil but saw minimal regrowth. They seek advice on styling and consider oral minoxidil and microneedling for denser hair.

      community Summaries of Finasteride Studies

      in Research/Science  20 upvotes 5 months ago
      Finasteride is effective in promoting hair growth and reversing hair miniaturization in men with androgenetic alopecia, with improvements seen in various studies over different durations. Some users report initial side effects like ball ache, which often resolve as the body adjusts.

      community An updated, simple guide to the most effective hair loss treatments

       193 upvotes 6 years ago
      Effective treatments for hair loss, including Dutasteride, Finasteride, Minoxidil, Dermarolling, LLLT, PRP, Ketoconazole, and Scalp Massage. In addition, anti-inflammatory diets and stress management are recommended to maintain or regrow hair.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 3 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

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