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research The role of androgen and androgen receptor in skin-related disorders

124 citations , July 2012 in “Archives of Dermatological Research”

This review discusses the roles of androgens and androgen receptors in skin-related disorders and suggests that targeting androgen receptors may be a more effective treatment strategy.

research The role of androgen therapy

24 citations , March 2003 in “Best Practice & Research Clinical Endocrinology & Metabolism”

This review discusses female androgen insufficiency syndrome and reports no new clinical results; the authors suggest that testosterone replacement may alleviate symptoms like loss of libido and fatigue.

research The role of androgen therapy

9 citations , June 2002 in “Best Practice & Research in Clinical Obstetrics & Gynaecology”

This review discusses androgen deficiency syndrome in women, its symptoms, and how androgen replacement therapy generally alleviates related issues without significant side-effects, but reports no new clinical findings.

research The Role of 11-Oxygenated Androgens and Endocrine Disruptors in Androgen Excess Disorders in Women

7 citations , September 2024 in “International Journal of Molecular Sciences”

This study found that 11-oxygenated androgens were higher in women with PCOS compared to those with idiopathic hirsutism, with no difference from controls, and higher Bisphenol A levels in obese women with PCOS may worsen metabolic issues.

research The role of prostaglandins in androgenetic alopecia

4 citations , February 2021 in “International Journal of Dermatology”

This study found that increased levels of PGD2 and prostacyclin and decreased levels of PGE2 and PGF2α were associated with baldness in androgenetic alopecia, suggesting potential targets for treatment.

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community Testosterone's Role In Androgenetic Alopecia

1 year ago

DHT is essential for androgenetic alopecia, not testosterone. Treatments like finasteride and dutasteride reduce DHT, halting hair loss.

community Perifollicular Fibrosis and its role in androgenetic alopecia. Is Aminexil/Kopexil a must for anyone with AGA?

5 upvotes 4 years ago

Aminexil/Kopexil may help reduce hair loss by addressing perifollicular fibrosis in androgenetic alopecia, but it lacks the extensive clinical backing of finasteride and minoxidil. Some users find it effective, but availability and cost are issues, especially in the US where it's not FDA-approved.

community Is there any role for topical DHT antagonists, or does a 5-AR inhibitor remove the need for them as therapy

2 upvotes 1 year ago

Topical androgen receptor antagonists may not be necessary if 5-AR inhibitors like finasteride or dutasteride effectively reduce DHT levels. Combining a 5-AR inhibitor with a topical androgen antagonist could potentially enhance treatment, but oral use of androgen antagonists is too risky due to severe side effects.

community Inflammation's surprising role in shrinking hair follicles and AGA

in Technology 66 upvotes 4 months ago

Inflammation plays a significant role in hair follicle miniaturization and androgenetic alopecia, with treatments like ketoconazole shampoo, minoxidil, and finasteride being used to address it. Users discuss the benefits of anti-inflammatory treatments and peptides like KPV, alongside traditional hair loss treatments, to improve scalp health and hair quality.

community Having androgen receptor density and sensitivity at wrong f*ing place

in Satire 7 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

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Learn

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learn Ketoconazole

antifungal with some anti-androgenic benefits, often used as a shampoo

learn Spironolactone

powerful topical and oral anti-androgen used mostly by women

Who can safely use spironolactone for hair thinning and androgen-related hair loss? Women with androgen-related hair loss can safely use spironolactone under medical supervision.

learn Minoxidil

An essential vasodilator with some anti-androgenic effects

learn Bicalutamide

a nonsteroidal anti-androgen, most commonly used orally for women

learn Finasteride

Frontline, gold standard treatment for combatting androgenic alopecia

Does hair strand thickness decrease in men with androgenic alopecia? Can finasteride help restore it? Androgenic alopecia thins hair strands by miniaturizing follicles. The pivotal finasteride trials (1,553 men, 1 mg/day, two years) report increased hair counts and improved assessed appearance, but they measured density, not the diameter of individual strands, so the effect on thickness itself is not established.

learn Argan oil

Argan oil: Is it useful for androgenic alopecia, or just for making hair look nice? Argan oil primarily improves hair appearance but lacks proven effectiveness for androgenic alopecia.

learn Metformin

Does metformin help control DHT levels that trigger androgenic alopecia? Metformin has been shown to lower circulating androgens in women with PCOS, but no published study has measured scalp DHT, 5-alpha reductase activity in the follicle, or hair density in anyone taking it — so its effect on pattern hair loss is untested, and it is not a DHT blocker.

learn Microneedling

Does microneedling help with all types of alopecia, or only androgenic alopecia? Microneedling is most effective for androgenic alopecia, with limited evidence for other types.

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