In this study, the researchers found that EGF and EGFR play crucial roles in goat fetal skin development, with their expression increasing progressively during gestation.
1 citations
,
January 2023 in “Cutis” This report discusses two cases where patients continued EGFR inhibitor therapy while receiving topical treatments for SDRIFE, highlighting the importance of dermatologists in managing such cutaneous adverse events without stopping cancer treatment.
4 citations
,
July 2024 in “Skin Research and Technology”
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reported significant transcriptomic changes in keratinocyte and immune cell populations in a mouse model with EGFR-deficient epidermis, suggesting possible targets for mitigating adverse skin events in EGFR-targeted cancer therapy.
December 2004 in “Differentiation” December 2024 in “International Journal of Advanced Research” In this study, researchers compared several commercial products for facial skin repair and found that only the product containing exosomes purified from bovine colostrum showed positive effects on cell proliferation, viability, and wound repair in vitro, outperforming untreated samples and other tested products.
This article provides a reference guide for various dermatological terms, treatments, and conditions, but reports no new clinical findings.
November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, topical application of adipose stem cell exosomes was found to reduce facial redness in atopic dermatitis patients treated with dupilumab, while improving skin hydration and decreasing inflammation markers over 12 weeks.
This study describes an adaptive hair extension method designed to improve comfort, durability, and aesthetics, based on analysis of hypothetical client profiles and their biomechanical tolerance.
8 citations
,
June 2022 in “International Journal of Molecular Sciences” This review discusses the potential of extracellular vesicles for facial aesthetic applications, including scar reduction and skin rejuvenation, but reports no new clinical results; further research into production and mechanisms is needed.
83 citations
,
May 2011 in “Experimental Dermatology” In this study, researchers identified nine new sheep keratin genes, highlighting species-specific differences in the expression and compartmentalization of wool-related keratin genes compared to humans.
June 2011 in “Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)” The researchers reported that both estrogen receptors ERα and ERβ are expressed in human testis, and identified two novel genes, Aven and Regucalcin, linked to estrogen and androgen regulation, which may be crucial for spermatogenesis.
19 citations
,
January 2015 in “Development” This study found that misexpression of Hoxc8 in mice led to ectopic mammary development and suggests Hox genes may play crucial roles in the regional specification and initiation of cutaneous accessory organs.
June 2026 in “Communications Biology” In this study, researchers found that the cornification process in the nuptial pads of Xenopus frogs involves the expression of the type II hair keratin homolog, krt59, and is regulated by the transcription factor hoxc13, showing similarities to mammalian hair evolution.
October 2023 in “Journal of the Endocrine Society” In this study, estetrol (E4) treatment was associated with increased hair growth in ex vivo human hair follicles, suggesting its potential as a treatment for hair loss disorders.
139 citations
,
May 2020 in “Stem Cell Research & Therapy” In this study, human bone marrow mesenchymal stem cell-derived exosomes significantly accelerated cutaneous wound healing in rats by modulating the TGF-β/Smad signaling pathway.
1 citations
,
May 2020 in “Research Square (Research Square)” This study found that human bone marrow mesenchymal stem cell-derived exosomes promote cutaneous wound healing in rats by inhibiting the TGF-β/Smad signaling pathway.
3 citations
,
August 2021 in “Research Square (Research Square)” This study found that increased mRNA expression of the Ectodysplasin-A2-Receptor, observed across multiple species and tissues, may exacerbate inflammation during aging, suggesting potential benefits of blocking EDA2R/EDA-A2 signaling.
38 citations
,
January 2011 in “PubMed” This review discusses the range of cutaneous side-effects caused by EGFR inhibitors in cancer therapy and explores available treatment options, without reporting new clinical findings.
February 2026 in “MDPI (MDPI AG)” This narrative review synthesizes findings suggesting that exosomes show promise for dermatological and regenerative applications, with early human studies indicating acceptable safety and potential benefits for wound care, rejuvenation, and alopecia, though clinical and regulatory development is still in its infancy.
16 citations
,
March 2025 in “International Journal of Molecular Sciences” This review analyzed 12 clinical studies on extracellular vesicle therapies, finding potential benefits for skin aging, acne scars, alopecia, and wound healing, but highlighted significant challenges like production standardization and lack of large-scale studies.
September 2023 in “Stem Cells International” This study using human and animal models found that adipose-derived stem cell exosomes promoted hair growth and counteracted dihydrotestosterone's inhibitory effects, suggesting potential therapeutic applications for androgenetic alopecia.
July 2026 in “Editora Pasteur eBooks” This study assesses the potential of exosomes as a therapeutic option for androgenetic alopecia, examining their mechanisms and effectiveness. The authors conducted a systematic review of existing research to explore how these extracellular vesicles might stimulate hair growth and restore follicle function.
23 citations
,
March 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that extracellular ATP released from UVB-irradiated keratinocytes promotes melanin production through the P2X7 receptor, indicating a role for ATP-P2X7 signaling in UV-induced melanogenesis.
January 1998 in “Dermatology” This abstract lists various medical conditions, treatments, and substances, but it does not report any new research findings.
2 citations
,
February 2023 in “International journal of molecular sciences” This study explored a multidimensional approach to examine body hairs' physico-chemical properties, potentially supporting their use over scalp hairs in forensic and intoxication studies.
40 citations
,
November 2021 in “International Journal of Molecular Sciences” This review highlights the role of keratin mutations in epidermolysis bullosa simplex and the resulting chronic inflammation, but it presents no new experimental findings.
137 citations
,
January 2000 in “Skin Pharmacology and Physiology” This review outlines the factors affecting skin greasiness and sebum production, highlighting measurement challenges but reports no new clinical findings; further research may guide sebosuppressive treatments for acne.
67 citations
,
January 2007 in “Climacteric” This article discusses the impact of estrogens on skin aging, highlighting the potential benefits and unresolved effectiveness of alternatives like phytoestrogens and selective estrogen receptor modulators; it reports no new clinical results.
13 citations
,
January 2021 in “Scientific Reports” This study found that Pannexin 3 plays a crucial role in skin development by regulating the transcription factor Epiprofin, affecting keratinocyte differentiation and hair follicle regeneration in mice.