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research Anthracycline analogs The past, present, and future
Epirubicin is as effective as doxorubicin for cancer treatment with less heart damage, but doesn't work on doxorubicin-resistant cancers.
research 068 Association of systemic involvement with skin morphology assessed by multiphoton microscopy in pseudoxanthoma elasticum
This study found no significant difference in SARS-CoV2 IgG seroconversion rates between patients with immune-mediated inflammatory diseases treated with targeted immune-modulating therapies and those on conventional systemic treatments.
research peri ‐Xanthenoxanthene (PXX): a Versatile Organic Photocatalyst in Organic Synthesis
This study reports that the dye peri-xanthenoxanthene (PXX) can act as an efficient photocatalyst for various radical reactions, including complex dual catalytic processes and the synthesis of an investigational drug intermediate.
research Aberrant expression of epidermal growth factor receptor in aural cholesteatoma
This study found that EGF receptors are aberrantly regulated and persist in cholesteatoma epithelium, suggesting a hyperproliferative character compared to normal human skin.
research Prevalence of Demodex spp. in students and employees of the Pomeranian Medical University in Szczecin
This study found that Demodex infestation was present in 21% of healthy volunteers, with higher rates in older individuals and more common in PUM personnel than students.
research Pharmacovigilance in Pediatric Patients with Epilepsy Using Antiepileptic Drugs
This study found that pediatric epilepsy patients on polytherapy experienced more adverse drug reactions compared to those on monotherapy, despite improved seizure control with polytherapy.
research Locally Synthetized 17-β-Estradiol Reverses Amyloid-β-42-Induced Hippocampal Long-Term Potentiation Deficits
This study found that boosting the synthesis of neural-derived 17β-estradiol effectively counteracted the impairment of hippocampal long-term potentiation caused by amyloid beta 1-42 in rat hippocampal slices, with the effect seemingly linked to glutamate NMDAR signaling.
research Expression analysis of proteasome maturation protein (POMP) gene in Liaoning Cashmere goat
This study observed that POMP is strongly expressed in the root sheath hair follicles of Liaoning Cashmere goats and its expression can be regulated by certain factors, which may influence cashmere growth.
research Electroosmotic pore transport in human skin.
research Eosinophilic Fasciitis Associated With Tryptophan Ingestion
In this study, researchers found that high-dose tryptophan ingestion before symptom onset may be linked to clinical features resembling eosinophilia-myalgia syndrome in patients with eosinophilic fasciitis.
research INTRODUCING OPTICAL MICROSCOPY METHODOLOGY DISPLAYING EMITTED ELECTROMAGNETIC ENERGY OF PRE-CANCEROUS SKIN SQUAMOUS CELL CARCINOMA
This article reviews a tabletop microscopy method for recording electromagnetic radiation from tissues, using hair follicles as a model, and presents no new clinical findings.
research Cosmeceutical Potentials of Equisetum debile Roxb. ex Vaucher Extracts
This study suggests that Equisetum debile extracts, particularly the ethyl acetate fraction, may offer natural cosmeceutical benefits for treating hyperpigmentation, delaying skin aging, and remediating hair loss due to androgenic alopecia.
research Immunohistochemical analysis of estrogen and progesterone receptors in endometrium and peritoneal endometriosis: A new quantitative method
This article discusses immunohistochemical analysis of estrogen and progesterone receptors in endometrium and peritoneal endometriosis, introducing a new quantitative method, but reports no new experimental results.
research 307 Phenotypic-genotypic expansion of plectinopathy in a patient with muscular dystrophy and immune-mediated myasthenia gravis
In this case study, a 26-year-old female with PLEC mutations and features of muscular dystrophy and myasthenia gravis showed significant improvement in symptoms following steroid treatment.
research Hairy‐Skin‐Adaptive Viscoelastic Dry Electrodes for Long‐Term Electrophysiological Monitoring
This study introduced a viscoelastic dry electrode that successfully reduces motion artifacts in EP monitoring on hairy skin, maintaining stable performance for up to 48 days.
research A Novel Model System to Identify Cellular and Molecular Defects Underlying Rare Genetic Disorders
This study developed an in vitro model using NTERT keratinocytes expressing AEC-related TP63 mutations, which replicated skin defects observed in AEC patients and offers a valuable tool for understanding the disorder and developing new treatments.
research Eosinophilic Pustular Folliculitis Mimicking Varicella: A Diagnostic Challenge in an Adolescent Patient
This case report highlights the importance of considering eosinophilic pustular folliculitis in adolescent patients with persistent papulopustular eruptions to avoid misdiagnosis and ensure effective anti-inflammatory treatment.
research A Case of pretibial myxedema with hyperthyroidism
This case report describes a 58-year-old man with pretibial myxedema and hyperthyroidism, highlighting his cardiac symptoms, exophthalmos, weight loss, and specific dermatological findings over the last four years.
research Erythema multiforme sparing regressing herpes zoster lesion: “Reverse isotopic phenomenon?”
A patient's skin rash did not affect the area where a previous viral rash was healing, suggesting a rare immune response.
research Pendekatan Diagnosis Ensefalomielitis Diseminata Akut
This article reviews acute disseminated encephalomyelitis, a neurological condition with demyelination of the central nervous system, and reports no new clinical findings; diagnosis is made by exclusion.
research 201 Pain digital biomarker detecting by epidermal biopotential flexible sensor and AI-based system
This study demonstrated that the Epidermal Biopotential Sensing System (EBSS) can measure digital biomarkers of pain in mice, suggesting potential applications in assessing pain and screening analgesics in populations with communication difficulties.
research Highlights from Recent Cancer Literature
This study found that MYH9 acts as a tumor suppressor in squamous cell carcinomas by stabilizing p53 in the nucleus, suggesting its role in cancer prevention.
research Research progress on the role of Epimedium in chronic bone and joint diseases
This study suggests that Epimedium can serve as a complementary and alternative treatment for chronic bone and joint diseases, potentially laying the groundwork for its clinical application.
research Logic-based modeling and drug repurposing for the prediction of novel therapeutic targets and combination regimens against E2F1-driven melanoma progression
In this study, researchers used computational modeling and virtual screening to identify two FDA-approved drugs, Tadalafil and Finasteride, that may effectively inhibit key proteins involved in melanoma progression, suggesting potential for new therapeutic strategies against aggressive melanoma.
research In vitro study of the antioxidant, sun factor protection, antimicrobial, and antifungal activities with molecular docking of methanolic extracts from leaves and fruit of Phillyrea angustifolia L.
research Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria
This study found that enzyme replacement therapy in mice with a severe form of classical homocystinuria improved metabolic patterns and alleviated many clinical symptoms.
research 원저 : 피부근염의 임상적 고찰
This study analyzed clinical manifestations in 18 dermatomyositis patients, noting that all exhibited skin rash and variable symptoms like itching and muscle weakness, with treatment involving prednisolone and hydroxychloroquine.
research Bioorthogonal Catalytic Microneedles Based on a Cytotoxic PEI Matrix for Synergistic Melanoma Therapy
This study introduced hydrogel microneedles loaded with palladium nanoparticles, which utilize the inherent cytotoxicity of polyethyleneimine to enhance the effectiveness of doxorubicin in treating melanoma, achieving a tumor inhibition rate of up to 98% in a murine model.
research Connection between granulosa cell pyroptosis and oocyte endoplasmic reticulum stress in a mouse model of polycystic ovary syndrome
This study found that in a mouse model of PCOS, high androgen levels caused pyroptosis in ovarian granulosa cells and increased ER stress in oocytes, reducing oocyte maturation rates, while treatment with CPA and DMF improved these rates.