Connection Between Granulosa Cell Pyroptosis and Oocyte Endoplasmic Reticulum Stress in a Mouse Model of Polycystic Ovary Syndrome
November 2025
in “
Journal of Ovarian Research
”
Studysummary This study found that in a mouse model of PCOS, high androgen levels caused pyroptosis in ovarian granulosa cells and increased ER stress in oocytes, reducing oocyte maturation rates, while treatment with CPA and DMF improved these rates.
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