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This study observed that repeated shaving and topical treatments, particularly TPA, stimulated hair regrowth in C3H mice, while certain treatments like betamethasone valerate completely inhibited it.

In this study, fraction No. 3 of Oryza sativa bran extract demonstrated high unsaturated fatty acid content and significant 5α-reductase inhibition, suggesting potential for developing anti-androgenic alopecia products.

This study found that angiogenin is expressed in human dermal papilla cells, where it might stimulate hair growth by promoting cell proliferation and local skin angiogenesis.

This study reports that newly synthesized steroidal trienones exhibit higher 5α-reductase inhibitory activity than dienones in various biological models, suggesting potential use in treating androgen-dependent diseases.

In this study, adipose tissue secretome was shown to enhance oxidative stress resistance and promote cell proliferation in vitiligo cells, suggesting a potential natural treatment approach.

This study found that the pH dependency of rat steroid 5α-reductase type II isozyme significantly affects its kinetic properties, including Vmax and Km, suggesting past discrepancies in literature may arise from these pH variances during assays.

This study found that 14 days of low-dose aspirin reduced the predicted response to topical minoxidil in androgenetic alopecia patients from 50% to 27%, suggesting aspirin may inhibit minoxidil efficacy.

This review explores various substances with potential antiandrogenic effects for treating acne, highlighting evidence for isotretinoin, and discusses the future consideration of 5 alpha-reductase inhibitors as antiandrogens.

This article reviews the potential of combining antiandrogenic and antiestrogenic treatments for BPH, highlighting aromatase inhibitors, but presents no new clinical results; further research is needed.

This study found that storing hair follicle micrografts in HEPES-buffered DMEM with ACD inhibitors like aminoguanidine significantly increased hair shaft elongation compared to phosphate-buffered salt solution, suggesting improved viability for transplantation.

This study found that direct interactions between human dermal papilla cells and melanocytes under low oxygen conditions improved cell functions and could be important for hair regeneration efforts.

This review discusses the efficacy and safety of exemestane as a treatment for estrogen-receptor-positive breast cancer and reports no new clinical results.

This study found that lower serum melatonin levels were associated with increased skin aging grades among individuals in Ulaanbaatar, suggesting melatonin loss may contribute to earlier skin aging.

This review explores enzyme inhibitors from gorgonians and soft corals and highlights their potential industrial and biomedical applications, but it reports no new experimental results.

This abstract reports funding sources for ongoing research and does not present any study results.

This theoretical study suggests that certain cannabinoid derivatives could potentially be effective as androgen receptor and 5α-reductase enzyme inhibitors, indicating they may be promising candidates for prostate cancer treatment based on their higher affinity to target proteins compared to standard drugs.

This study found that the combined use of sugarcane fibre and keratinolytic enzymes reduced hairball excretion in cats.

This narrative review discusses various causes and treatments of hirsutism in women, emphasizing the importance of identifying androgen-secreting tumors, but does not present new study results.

This review suggests that GABAergic neuroactive steroids modulated by alcohol could play a role in vulnerability to alcohol use disorders, providing a rationale for further therapeutic exploration.

This chapter discusses genetic polymorphisms related to phenotypes that differentiate between populations and reports no new results; it highlights the role of DNA technology in understanding human adaptation history.

This review suggests that female and male hair loss patterns differ due to hormonal influences, metabolic factors, and genetic loci, with female pattern hair loss potentially occurring without androgen influence, highlighting the need for distinct clinical management approaches.

In this study, researchers using QM/MM simulations identified key molecular motions and residue interactions in the enzyme SRD5A2 that significantly influence its catalytic efficiency, demonstrating that specific residues play critical roles in stabilizing transition states and reducing activation barriers.

This study found that combining Alexandrite laser with iontophoresis of chymotrypsin and papain enzymes reduced the laser pulse requirements compared to laser alone for treating paradoxical hypertrichosis in women with facial hirsutism, suggesting potential clinical benefits in managing this condition.

In this study, researchers observed that chronic stress affected wild-derived house mice differently by sex, with females showing less weight gain and distinct behavioral changes, while males exhibited higher hair corticosterone levels, suggesting divergent coping strategies and implications for sex-specific stress assessment protocols.

This perspective reviews enzyme-instructed self-assembly (EISA) as a conceptual framework for supramolecular chemical biology, emphasizing its innovative role in developing adaptive biomaterials and synthetic cellular machines without providing new experimental results.

In this study, chronic unpredictable stress affected male and female wild-derived house mice differently; stressed females gained less weight, had long grooming times, and lower immobility in tests, while stressed males showed increased hair corticosterone levels and shorter immobility times.

This study found that hair testosterone concentrations show some consistency over time, but factors like hair washing and individual growth rates influence these levels, suggesting the need for careful sampling and analysis adjustments.

This study found that individuals with premature hair graying had significantly lower levels of antioxidants compared to controls, but the severity of graying did not significantly correlate with oxidative stress levels.

This article discusses the widespread issue of zinc deficiency affecting plant, animal, and human health, and reports no new clinical results; the authors emphasize the need for adequate zinc availability in agriculture and nutrition.

This review discusses the influence of androgens on opioid-mediated effects and calls for further research into their role in sex differences and potential therapeutic options for chronic pain and substance use disorders.