Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study describes the enzymatic processes through which DHEA is converted to active sex steroids in human skin, highlighting an androgenic effect on sebaceous glands and estrogenic effects in the vagina.

This article highlights studies on cholesterol transporter proteins in hair cycles, epithelial-to-mesenchymal transition in cancer, ovarian hormone effects on cell polarity before implantation, and UV effects on rodent skin, without providing new clinical results.

This article discusses immunohistochemical analysis of estrogen and progesterone receptors in endometrium and peritoneal endometriosis, introducing a new quantitative method, but reports no new experimental results.

This study found that multiphoton microscopy imaging allows for detailed observation and quantitative analysis of collagen alterations in the progression of endometrial cancer, potentially offering a faster, more accurate method for early diagnosis compared to current protocols.

This study found that GTx-024 and Danazol had similar effects to dihydrotestosterone on uterine tissue in mice, while GTx-007 showed minimal impact on the parameters tested.

This study found that impaired autophagy plays a role in sonic hedgehog pathway-induced endometrial fibrosis, suggesting it as a potential target for treating intrauterine adhesion.

This study found that administering testosterone to ovariectomized female rats decreased endometrial tight junction complexity and expression of specific proteins, potentially affecting embryo implantation.

This study suggests that 5α-reductase-mediated metabolism of progesterone contributes to the differentiation of endometrial stromal cells, potentially influencing progesterone levels and promoting cell differentiation.

This study found that intrauterine administration of botulinum toxin A improved endometrial environment and receptivity in a murine model of thin endometrium through mechanisms involving IGFBP3 and osteopontin.

This study found that intracrine androgen signaling, mediated by steroid 5α-reductase, is essential for optimal decidualization and vascular development in the endometrium during pregnancy, indicating potential targets for improving age-related fertility issues.

This study found increased IL-18 levels in the endometrium of women with polycystic ovary syndrome, especially in those who are overweight, suggesting a link with body mass index.

This study reviews the causes, mechanisms, and treatments for thin endometrium, highlighting multiple contributing factors such as hormonal influences, long-term oral contraceptive use, and uterine inflammation, while noting unclear mechanisms in promising therapeutic strategies like pharmacological treatments and regenerative medicine approaches.

This study found that depletion of KRT17 in endometrial cancer reduced cell growth, motility, and angiogenesis, suggesting KRT17 as a potential therapeutic target.

This review discusses the potential benefits of using autologous endometrial cells and PRP via hysteroscopic injections to improve pregnancy outcomes in ART, particularly in individuals with refractory thin endometrium, but reports no new clinical results.

This study found that obesity in women may impair endometrial stromal function and contribute to reproductive complications, possibly due to metabolic influences rather than immune cell differences.

In this review, the researchers detailed how the p63 transcription factor influences epithelial stem cell activities such as self-renewal, differentiation, and proliferation, highlighting the role of TAp63 and ΔNp63 isoforms in both normal tissue development and cancer pathogenesis.

This review discusses how androgens, commonly known for male reproductive roles, also influence the physiology and pathology of the human endometrium, though their exact roles in this tissue remain controversial and not fully understood.

This review discusses the role of platelet-rich plasma in assisted reproductive technology for enhancing endometrial receptivity and reports promising outcomes.

This review discusses the role of keratins in epithelial cell stress protection and cancer, highlighting their potential as multifunctional regulators and diagnostic markers, without presenting new research findings.

This study found that prostaglandin D2 reduced proliferation in bulge resident K15+ stem cells but not in other K15+ progenitor cells, suggesting differential impacts on hair follicle stem cell niches.

This article lacks an abstract and reports no new findings.

This study found that Wnt7a protein expression increased after corneal epithelial injury and promoted human corneal epithelium cell proliferation by upregulating fibronectin and enhancing cell adhesion.

This study found that intracrine androgen signaling via 5α-reductase is essential for optimal endometrial decidualization and vascular development during this process in mice.

This review discusses the use of testosterone therapy for low libido in women, noting mixed evidence on breast cancer risk and a lack of long-term safety data.

In this case report, a 54-year-old woman with hirsutism was found to have a benign ovarian cystadenofibroma, which resolved after surgery, highlighting the importance of evaluating postmenopausal women for ovarian causes of androgen excess.

This meta-analysis reports that intrauterine autologous platelet-rich plasma infusion improved outcomes like endometrial thickness and clinical pregnancy rate in women with thin endometrium, but further large-scale trials are needed to confirm these findings.

This paper discusses the role of Runx1 in epithelial biology and pathology, highlighting its dual function as a tumor promoter and suppressor in different contexts, and reports no new experimental findings.

This study reports that the autotaxin–LPA–LPA3 signaling pathway at the embryo-epithelial boundary plays a critical role in decidualization by up-regulating HB-EGF and COX-2 in the uterine epithelium.

This review discusses the effects and selection criteria of different progestogens in various treatments but reports no direct clinical comparisons of their metabolic effects.

This study found that intrauterine PRP infusion is a safe and effective treatment for patients with refractory thin endometrium and implantation failures, with the improvement primarily driven by the angiogenic cytokines in PRP.