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Diagnosing and treating PCOS is complex due to differing criteria and requires a team approach.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.

The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Transplant success has improved with better immunosuppressive drugs and donor matching.

Flutamide effectively reduced excessive hair growth and improved related symptoms in hirsutism patients without significant side effects.

Metformin improves hair growth and menstrual frequency in women with PCOS and hirsutism.

Shrinking skin cancer increases the chance of cancer in nearby lymph nodes.

The conclusion is that the best initial treatment for hirsutism is usually oral contraceptives, with the addition of antiandrogens or insulin sensitizers if needed, and topical eflornithine or laser treatments as supplementary options.

Myo-inositol helps improve skin conditions and metabolic profiles in young women with PCOS.

Finasteride effectively treats hirsutism in women, but more research needed for long-term results.

The conclusion is that we need more effective hair loss treatments than the current ones, and these could include new drugs, gene and stem cell therapy, hormones, and scalp cooling, but they all need thorough safety testing.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Mice skin has components that could help with hair growth and might be used for diabetes treatment.

Skin and hair can help us understand organ regeneration, especially how certain stem cells might be used to form new organs.

Long-term fluticasone treatment does not harm the immune system in horses with heaves.

Certain HSD3B1 gene types are linked to worse prostate cancer outcomes and affect treatment response and other health conditions.

Finasteride reduces hirsutism effectively with fewer side effects but is a second-choice treatment due to safety concerns.

The document says that understanding the causes of PCOS is important for treatment, especially in distinguishing the syndrome from just having cystic ovaries, and that losing weight is key for obese women with PCOS.

Finasteride 1 mg helps prevent more hair loss in men with male pattern baldness.

The research suggests that the ZP4 gene is linked to egg development in women with PCOS but requires more study to understand its role in infertility.

Spironolactone can reduce hair growth and testosterone in hirsutism, but is less effective than combined treatments.

Leptin affects skin and hair health and may worsen some skin conditions, but more research is needed to understand its full impact.

Finasteride shows promise for treating hair loss and excessive hair growth, but more research is needed to confirm its effectiveness and safety.

Anti-Müllerian hormone is a specific marker for ovarian issues in women with conditions like PCOS.

Early treatment and lifestyle changes are important for managing PCOS in young people to prevent long-term health issues.

Spironolactone is a low-cost, effective, and generally safe treatment for various skin conditions related to hormones.

Finasteride can cause sexual dysfunction and depression, which may persist and require hormonal treatment.