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    Glossary EDAR gene

    provides instructions for a protein crucial in hair development

    The EDAR gene provides instructions for making a protein that is crucial for the development of hair, teeth, and sweat glands. Mutations in this gene can lead to conditions like hypohidrotic ectodermal dysplasia, which affects these structures, resulting in sparse hair, missing teeth, and reduced ability to sweat.

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    Research 30 of 385

    1. A replication study confirmed the EDAR gene to be a major contributor to population differentiation regarding head hair thickness in Asia Human genetics · 2008 · 89 citations
    2. Combination of Transcriptomics and Proteomics Reveals Differentially Expressed Genes and Proteins in the Skin of EDAR Gene-Targeted and Wildtype Cashmere Goats Animals · 2023 · 1 citations
    3. Mutational spectrum of EDA, EDAR, EDARADD, and WNT10A genes in the largest cohort of Russian patients with hypohidrotic ectodermal dysplasia Orphanet Journal of Rare Diseases · 2026
    4. EDA and EDAR expression at different stages of hair follicle development in cashmere goats and effects on expression of related genes 2020 · 12 citations
    5. Enhanced ectodysplasin-A receptor (EDAR) signaling alters multiple fiber characteristics to produce the East Asian hair form Human mutation · 2008 · 98 citations
    6. Generation of Cashmere Goats Carrying an <i>EDAR</i> Gene Mutant Using CRISPR-Cas9-Mediated Genome Editing International Journal of Biological Sciences · 2018 · 33 citations
    7. Novel missense mutation in the EDA gene in a family affected by oligodontia 2016 · 12 citations
    8. Hair shaft structures in EDAR induced ectodermal dysplasia BMC Medical Genetics · 2015 · 5 citations
    9. Advances in the genetic understanding of hypohidrotic ectodermal dysplasia Expert opinion on orphan drugs · 2017 · 1 citations
    10. Divergent genetic mechanism leads to spiny hair in rodents bioRxiv (Cold Spring Harbor Laboratory) · 2018
    11. Genetic Mapping Of Hereditary Ectodermal Dysplasias And Hair Loss Genes 2011
    12. INDENTIFICATION OF GENES INVOLVED IN INHERITED ECTODERMAL DYSPLASIAS 2008
    13. Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis Development · 2000 · 208 citations
    14. Current Genetics in Hair Diseases InTech eBooks · 2013 · 1 citations
    15. Facial skin aging: an integrative analysis of genetics, epigenetics, and lifestyle factors GeroScience · 2025
    16. Involvement of the Edar Signaling in the Control of Hair Follicle Involution (Catagen) ˜The œAmerican journal of pathology · 2006 · 43 citations
    17. Genetics of Alopecia Encyclopedia of Life Sciences · 2012
    18. Biology and Genetics of Hair Annual Review of Genomics and Human Genetics · 2010 · 89 citations
    19. Identification of Ectodysplasin Target Genes Reveals the Involvement of Chemokines in Hair Development 2012 · 48 citations
    20. m6A Methylation Analysis Reveals Networks and Key Genes Underlying the Coarse and Fine Wool Traits in a Full-sib Merino Family Biology · 2022 · 9 citations
    21. Asian Hair: A Review of Structures, Properties, and Distinctive Disorders Clinical, Cosmetic and Investigational Dermatology · 2020 · 39 citations
    22. Dumhetens rum i bildningens mitt International Journal of Biological Sciences · 2013
    23. Research Snippets British Journal of Dermatology · 2005
    24. Global Landscapes of Human Phenotypic Variation in Inherited Traits Evolutionary studies · 2017 · 1 citations
    25. Transcriptome Reveals Long Non-coding RNAs and mRNAs Involved in Primary Wool Follicle Induction in Carpet Sheep Fetal Skin Frontiers in physiology · 2018 · 37 citations
    26. A Comprehensive Review of GWASs of Human Hair Traits Journal of Investigative Dermatology · 2025 · 1 citations
    27. Interplay between EDA-EDAR and WNT signalling pathways in the development of skin appendages in hypohidrotic ectodermal dysplasia Pediatria i Medycyna Rodzinna · 2025 · 1 citations
    28. Two mutations at KRT74 and EDAR synergistically drive the fine-wool production in Chinese sheep Journal of Advanced Research · 2023 · 2 citations
    29. Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations Scientific reports · 2018 · 58 citations
    30. Inherited Disorders of the Hair Elsevier eBooks · 2013 · 2 citations