research Hair Problems in Women: A 1997 Study on Prevalence, Psychological Impact, and Treatment Approaches
Hair problems are common and distressing for women, but increasing knowledge of treatments offers hope.
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research Multi-Potentiality of a New Immortalized Epithelial Stem Cell Line Derived from Human Hair Follicles
Scientists created a long-lasting stem cell line from human hair that can turn into different skin and hair cell types.
research Mutational Spectrum in 101 Patients with Hypohidrotic Ectodermal Dysplasia and Breakpoint Mapping in Independent Cases of Rare Genomic Rearrangements
Researchers found genetic mutations causing hypohidrotic ectodermal dysplasia in 88% of studied patients and identified new mutations and genetic variations affecting the disease.
research Successful Treatment of Female-Pattern Hair Loss with Spironolactone in a 9-Year-Old Girl
Spironolactone successfully treated hair loss in a 9-year-old girl.
research The Notch Intracellular Domain Has an RBPj-Independent Role During Mouse Hair Follicular Development
The Notch signaling pathway helps in mouse hair development through a noncanonical mechanism that does not rely on RBPj or transcription.
research Vitamin D Resistance: Tissue Resistance to Vitamin D and Vitamin D-Dependent Rickets Types I and II
Some people have genetic mutations that make them resistant to vitamin D, leading to rickets even with enough vitamin D intake.
research Atrichia With Papular Lesions
Accurate diagnosis of APL is crucial to avoid unnecessary treatments.
research Rickets with Alopecia: Remission Following a Course of 1-Alpha-Hydroxy Vitamin D3 Therapy
Child with rickets improved with a specific vitamin D therapy, but alopecia did not change.
research Beard Transplants and Facial Hair Trends: Why Men Are Motivated to Have Surgery
Men are getting more beard transplants to look better and follow fashion trends.
research A Rare Case of Hereditary 1,25-Dihydroxyvitamin D Resistant Rickets
A rare genetic mutation causes resistance to vitamin D, leading to severe rickets and requiring high doses of calcium and vitamin D for treatment.
research Gene Therapy for Alopecia in Type II Rickets Model Rats Using Vitamin D Receptor-Expressing Adenovirus Vector
Gene therapy helped rats with a specific type of rickets grow hair without severe inflammation.
research Congenital Atrichia: A Case Report
Genetic testing is crucial for diagnosing congenital atrichia, a rare condition causing irreversible hair loss.
research Altered Hair Root Gene Expression Profiles Highlight Calcium Signaling and Lipid Metabolism Pathways Associated With Curly Hair Initiation and Maintenance in Mangalitza Pigs
Genes related to calcium signaling and lipid metabolism are important for curly hair in Mangalitza pigs.
research Skin Changes on the Face Caused by Over-The-Counter Cosmetic Creams: An Observational Study of Clinical and Dermoscopy Features
Over-the-counter cosmetic creams can cause skin damage on the face that is visible under dermoscopy and confirmed by tissue analysis.
research Dynein Is Involved in the Movement, Distribution, Acidity, and Transfer of Melanosomes
Dynlt3 is important for melanosome transport and skin coloration.
research Hairy Math: Addition of Wnt-3a to Multiply Bulge Cells
Wnt-3a helps grow more skin stem cells, which could lead to new hair loss treatments.
research Dihydrotestosterone Stimulates 5α-Reductase Activity in Pubic Skin Fibroblasts
Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.
research P21Waf1/Cip1 Is Differentially Expressed in Epidermal Versus Follicular Melanocytes and Melanoma Cells and Is Phenotypically Regulated by UVB-Mediated Apoptosis
The protein p21 is more abundant in normal skin cells than in melanoma cells and may help protect against melanoma, with UVB light affecting its levels.
research Androgen-Induced Norepinephrine Release in Male Accessory Sex Organ Smooth Muscle Growth and Differentiation
Androgens increase norepinephrine release, promoting smooth muscle growth in male sex organs, which may contribute to benign prostatic hypertrophy.
research Endocrinology Update: Hirsutism
Hirsutism was characterized by excessive terminal hair growth in a male pattern on androgen-dependent areas of the female body, and it could occur in both men and women. The condition was commonly associated with polycystic ovary syndrome, idiopathic hyperandrogenemia, and other endocrine disorders. Diagnostic guidelines primarily focused on premenopausal women, but evaluations for underlying endocrinopathies in postmenopausal women and men were also necessary. Management strategies included eliminating causative drugs, assessing hypothalamic-pituitary-gonadal axis dysregulation, and identifying androgen-secreting tumors. Treatment options involved pharmacotherapy with estrogens-progestins, antiandrogens, and other agents, while surgical excision was considered for certain adenomas.
research The Long Road Traveled in Hematopoietic Stem Cell Gene Therapy
The FDA approved the first gene therapy for a blood disorder after overcoming early challenges and demonstrating patient benefits.
research Dose-Response Relationship of Therapeutic Oxygen: More Is Not Necessarily Better and May Be Inferior to No Supplemental Oxygen – Part 2: Implications and Consequences
More oxygen isn't always better and can sometimes be worse.
research A Rapidly Progressive Case of Skin and Soft Tissues Necrosis in a COVID-19 Positive Patient
COVID-19 may lead to severe skin necrosis without clear underlying causes, as seen in a diabetic patient who required leg amputation.
research Finasteride And Dutasteride May Reduce Melanoma Risk
Finasteride and dutasteride might lower melanoma risk.
research Wnt Signaling and Aging-Related Heart Disorders
Wnt signaling may be linked to heart diseases in aging and could be a target for future treatments.
research Synthesis of Inositol in Mice
Mice need pantothenic acid to make inositol.
research Antiandrogens: Clinical Applications
Antiandrogens help treat hormone-related conditions in both men and women.
research Epidermal Growth Factor Promotes Proliferation of Dermal Papilla Cells via Notch Signaling Pathway
A substance called epidermal growth factor helps increase the growth of important hair follicle cells by activating a specific cell communication route.
research Current Treatments for Alopecia Areata
There is no cure for alopecia areata, but treatments like JAK inhibitors show promise.
research Dietary Vitamin A Regulates Wingless-Related MMTV Integration Site Signaling to Alter the Hair Cycle
Eating vitamin A affects hair growth and health by changing cell signals in mice.