Dose-Response Relationship of Therapeutic Oxygen: More Is Not Necessarily Better and May Be Inferior to No Supplemental Oxygen – Part 2: Implications and Consequences

The document emphasizes that the therapeutic use of oxygen follows a dose-dependent, biphasic dose-response relationship, where lower doses are beneficial, but higher doses can be harmful. It reviews various studies and clinical trials, highlighting that hyperbaric oxygen therapy (HBOT) is not always superior to normobaric oxygen therapy (NBOT) for conditions like wound healing, neurological disorders, and sports injuries. The findings suggest that understanding the appropriate oxygen dose can improve patient outcomes, expand the applications of hyperoxic therapy, and reduce healthcare costs.