A Rapidly Progressive Case of Skin and Soft Tissues Necrosis in a COVID-19 Positive Patient

June 2022

Severino Persechino

skin necrosis soft tissue necrosis osteomyelitis vascular-related skin necrosis bacterial superinfection corticosteroids advanced wound care skin death bone infection steroids wound care

TLDR COVID-19 may lead to severe skin necrosis without clear underlying causes, as seen in a diabetic patient who required leg amputation.

This case report details a 68-year-old male with controlled insulin-dependent diabetes who experienced severe skin and soft tissue necrosis on his lower limbs during a mild COVID-19 infection. Despite no signs of vasculitis or thrombotic occlusion and negative blood cultures, the patient's condition worsened, resulting in osteomyelitis and necessitating leg amputation. Treatment included antibiotics, corticosteroids, and advanced wound care. The report suggests that COVID-19 may cause severe vascular-related skin necrosis, though the exact mechanisms are unknown. The authors propose that the viral infection initiated the necrosis, with bacterial superinfection aggravating the condition.

View this study on athenaeumpub.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community If Minoxidil Beards are permanent, why should Finasteride be unable to keep Minoxidil Gains on the scalp?

in Minoxidil 104 upvotes 1 year ago

Whether Finasteride can keep alive the hair gained by Minoxidil after quitting it, and why beard hairs are not as susceptible to miniaturization. It is suggested that scalp hair may be dependent on Minoxidil and that DHT could be countered with Finasteride to some extent, but there is no definitive data proving this.

community My hair loss theory and what I did to stop my hair loss. 6 years of stabilization.

in Treatment 7 upvotes 4 years ago

A user shared their personal theory on hair loss, suggesting it's caused by reduced blood flow and scalp calcification rather than DHT, and claimed to have stopped their hair loss by massaging the scalp, using acid peels, and applying oils and copper peptides. They have not noticed further hair loss for six years since starting this routine.

community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

in Research/Science 14 upvotes 5 months ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

community DIY Dutasteride Mesotherapy....THE ULTIMATE EXPERIMENT WITH RESULTS!

in Finasteride/Dutasteride 155 upvotes 3 years ago

User tried DIY Dutasteride Mesotherapy for hair loss due to unsatisfactory Finasteride results. Used mesotherapy injection gun and liquid dutasteride for better results and fewer side effects.

community Huge holes on donor area of scalp is this even normal?

in Transplants 106 upvotes 11 months ago

The conversation is about a person experiencing significant hair loss in the donor area after a hair transplant, with others suggesting it might be shock loss. The person is taking oral minoxidil and dutasteride to help with the issue.

community What an amazing time to be alive

in Finasteride/Dutasteride 184 upvotes 1 year ago

The post discusses a user's experience with hair loss treatments, specifically topical finasteride, minoxidil, and micro-needling, and their plan to switch to oral versions and add Dutasteride. The conversation includes various responses, with some users sharing their own experiences and side effects, and others expressing desire for a more permanent hair loss solution.

Related Research

1 / 1 results

research A Rapidly Progressive Case of Skin and Soft Tissues Necrosis in a COVID-19 Positive Patient

June 2022

COVID-19 may lead to severe skin necrosis without clear underlying causes, as seen in a diabetic patient who required leg amputation.