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PPAR agonists show promise for skin conditions but need more research before being a main treatment.

MOF controls key genes for skin development by regulating mitochondrial and ciliary functions.

Protease Nexin-1 is found in human hair growth cells and is affected by male hormones.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

Estrogen therapy can reduce skin aging but has cancer risks.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.

The three estrogen receptor genes are highly expressed in zebrafish neuromasts during development.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.

The Androgen Receptor could be a target for treating diseases like cancer, but more research is needed to confirm the effectiveness of potential treatments.

We need better ways to test and understand SARMs to make safer and more effective treatments.

A Chinese family had a child with a specific gene mutation causing vitamin D-resistant rickets, but the child improved with calcium and low-dose calcitriol.

Runx genes are important for stem cell regulation and their roles in aging and disease need more research.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

The conclusion is that the nuclear lamina and LINC complex in skin cells respond to mechanical signals, affecting gene expression and cell differentiation, which is important for skin health and can impact skin diseases.

Hormones, especially testosterone and DHT, are key for penis development and function, and testosterone therapy may help with erectile dysfunction in those with low levels.

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

FOXN1 gene mutations cause a rare, severe immune disease treatable with cell or tissue transplants.

Testing for CAG repeat polymorphism in the androgen receptor gene is not currently recommended for managing hypogonadism.

TAF4 is important for skin cell growth and helps prevent skin cancer in mice.

The conclusion is that androgenetic alopecia and senescent alopecia have unique gene changes, suggesting different causes and potential treatments for these hair loss types.

Mutations in certain receptors can cause diseases and offer new treatment options.